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Rapidly Fatal Radiation-induced Glioblastoma
Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507665/ https://www.ncbi.nlm.nih.gov/pubmed/28706761 http://dx.doi.org/10.7759/cureus.1336 |
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author | Ng, Ivy Tan, Char Loo Yeo, Tseng Tsai Vellayappan, Balamurugan |
author_facet | Ng, Ivy Tan, Char Loo Yeo, Tseng Tsai Vellayappan, Balamurugan |
author_sort | Ng, Ivy |
collection | PubMed |
description | Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agents, prior radiation exposure may play a role. We report on a patient who had been treated six years prior for a vestibular schwannoma with high-dose conventional radiotherapy and subsequently developed a rapidly fatal glioblastoma at the same location. The diagnosis was confirmed by routine histopathology as well as more advanced techniques, such as whole genome copy number analysis. |
format | Online Article Text |
id | pubmed-5507665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-55076652017-07-13 Rapidly Fatal Radiation-induced Glioblastoma Ng, Ivy Tan, Char Loo Yeo, Tseng Tsai Vellayappan, Balamurugan Cureus Neurosurgery Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agents, prior radiation exposure may play a role. We report on a patient who had been treated six years prior for a vestibular schwannoma with high-dose conventional radiotherapy and subsequently developed a rapidly fatal glioblastoma at the same location. The diagnosis was confirmed by routine histopathology as well as more advanced techniques, such as whole genome copy number analysis. Cureus 2017-06-11 /pmc/articles/PMC5507665/ /pubmed/28706761 http://dx.doi.org/10.7759/cureus.1336 Text en Copyright © 2017, Ng et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurosurgery Ng, Ivy Tan, Char Loo Yeo, Tseng Tsai Vellayappan, Balamurugan Rapidly Fatal Radiation-induced Glioblastoma |
title | Rapidly Fatal Radiation-induced Glioblastoma |
title_full | Rapidly Fatal Radiation-induced Glioblastoma |
title_fullStr | Rapidly Fatal Radiation-induced Glioblastoma |
title_full_unstemmed | Rapidly Fatal Radiation-induced Glioblastoma |
title_short | Rapidly Fatal Radiation-induced Glioblastoma |
title_sort | rapidly fatal radiation-induced glioblastoma |
topic | Neurosurgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507665/ https://www.ncbi.nlm.nih.gov/pubmed/28706761 http://dx.doi.org/10.7759/cureus.1336 |
work_keys_str_mv | AT ngivy rapidlyfatalradiationinducedglioblastoma AT tancharloo rapidlyfatalradiationinducedglioblastoma AT yeotsengtsai rapidlyfatalradiationinducedglioblastoma AT vellayappanbalamurugan rapidlyfatalradiationinducedglioblastoma |