Differential role of pannexin-1/ATP/P2X(7) axis in IL-1β release by human monocytes

IL-1β release is integral to the innate immune system. The release of mature IL-1β depends on 2 regulated events: the de novo induction of pro-IL-1β, generally via NF-κB-dependent transduction pathways; and the assembly and activation of the NLRP3 inflammasome. This latter step is reliant on active...

Descripción completa

Detalles Bibliográficos
Autores principales: Parzych, Katarzyna, Zetterqvist, Anna V., Wright, William R., Kirkby, Nicholas S., Mitchell, Jane A., Paul-Clark, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507675/
https://www.ncbi.nlm.nih.gov/pubmed/28246166
http://dx.doi.org/10.1096/fj.201600256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507675/
https://www.ncbi.nlm.nih.gov/pubmed/28246166
http://dx.doi.org/10.1096/fj.201600256

Ejemplares similares