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Differential role of pannexin-1/ATP/P2X(7) axis in IL-1β release by human monocytes

IL-1β release is integral to the innate immune system. The release of mature IL-1β depends on 2 regulated events: the de novo induction of pro-IL-1β, generally via NF-κB-dependent transduction pathways; and the assembly and activation of the NLRP3 inflammasome. This latter step is reliant on active...

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Detalles Bibliográficos
Autores principales:	Parzych, Katarzyna, Zetterqvist, Anna V., Wright, William R., Kirkby, Nicholas S., Mitchell, Jane A., Paul-Clark, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507675/ https://www.ncbi.nlm.nih.gov/pubmed/28246166 http://dx.doi.org/10.1096/fj.201600256

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