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Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model

Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepr...

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Autores principales: Lee, Hwayoung, Im, Jiyun, Won, Hansol, Nam, Wooyoung, Kim, Young Ock, Lee, Sang Won, Lee, Sanghyun, Cho, Ik-Hyun, Kim, Hyung-Ki, Kwon, Jun-Tack, Kim, Hak-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507774/
https://www.ncbi.nlm.nih.gov/pubmed/28706449
http://dx.doi.org/10.4196/kjpp.2017.21.4.361
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author Lee, Hwayoung
Im, Jiyun
Won, Hansol
Nam, Wooyoung
Kim, Young Ock
Lee, Sang Won
Lee, Sanghyun
Cho, Ik-Hyun
Kim, Hyung-Ki
Kwon, Jun-Tack
Kim, Hak-Jae
author_facet Lee, Hwayoung
Im, Jiyun
Won, Hansol
Nam, Wooyoung
Kim, Young Ock
Lee, Sang Won
Lee, Sanghyun
Cho, Ik-Hyun
Kim, Hyung-Ki
Kwon, Jun-Tack
Kim, Hak-Jae
author_sort Lee, Hwayoung
collection PubMed
description Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that pain threshold was significantly decreased in the FM group compared to that in the control group. Western blot and immunohistochemical analyses of medial prefrontal cortex (mPFC) and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to the control group. However, tianeptine recovered these changes in behavioral tests and protein level. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNF-CREB pathway and pain. Our results suggest that tianeptine might potentially have therapeutic efficacy for FM.
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spelling pubmed-55077742017-07-13 Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model Lee, Hwayoung Im, Jiyun Won, Hansol Nam, Wooyoung Kim, Young Ock Lee, Sang Won Lee, Sanghyun Cho, Ik-Hyun Kim, Hyung-Ki Kwon, Jun-Tack Kim, Hak-Jae Korean J Physiol Pharmacol Original Article Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that pain threshold was significantly decreased in the FM group compared to that in the control group. Western blot and immunohistochemical analyses of medial prefrontal cortex (mPFC) and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to the control group. However, tianeptine recovered these changes in behavioral tests and protein level. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNF-CREB pathway and pain. Our results suggest that tianeptine might potentially have therapeutic efficacy for FM. The Korean Physiological Society and The Korean Society of Pharmacology 2017-07 2017-06-26 /pmc/articles/PMC5507774/ /pubmed/28706449 http://dx.doi.org/10.4196/kjpp.2017.21.4.361 Text en Copyright © Korean J Physiol Pharmacol http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Hwayoung
Im, Jiyun
Won, Hansol
Nam, Wooyoung
Kim, Young Ock
Lee, Sang Won
Lee, Sanghyun
Cho, Ik-Hyun
Kim, Hyung-Ki
Kwon, Jun-Tack
Kim, Hak-Jae
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title_full Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title_fullStr Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title_full_unstemmed Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title_short Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
title_sort effects of tianeptine on symptoms of fibromyalgia via bdnf signaling in a fibromyalgia animal model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507774/
https://www.ncbi.nlm.nih.gov/pubmed/28706449
http://dx.doi.org/10.4196/kjpp.2017.21.4.361
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