Cargando…
Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon
PURPOSE: To evaluate whether the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon could reflect the genomic information of breast cancers and to suggest intuitive imaging features as biomarkers. METHODS: Matched breast MRI data from The Cancer Imaging Archive and gene expression profil...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507787/ https://www.ncbi.nlm.nih.gov/pubmed/28706887 http://dx.doi.org/10.4174/astr.2017.93.1.18 |
_version_ | 1783249779274285056 |
---|---|
author | Kim, Ga Ram Ku, You Jin Cho, Soon Gu Kim, Sei Joong Min, Byung Soh |
author_facet | Kim, Ga Ram Ku, You Jin Cho, Soon Gu Kim, Sei Joong Min, Byung Soh |
author_sort | Kim, Ga Ram |
collection | PubMed |
description | PURPOSE: To evaluate whether the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon could reflect the genomic information of breast cancers and to suggest intuitive imaging features as biomarkers. METHODS: Matched breast MRI data from The Cancer Imaging Archive and gene expression profile from The Cancer Genome Atlas of 70 invasive breast cancers were analyzed. Magnetic resonance images were reviewed according to the BI-RADS MRI lexicon of mass morphology. The cancers were divided into 2 groups of gene clustering by gene set enrichment an alysis. Clinicopathologic and imaging characteristics were compared between the 2 groups. RESULTS: The luminal subtype was predominant in the group 1 gene set and the triple-negative subtype was predominant in the group 2 gene set (55 of 56, 98.2% vs. 9 of 14, 64.3%). Internal enhancement descriptors were different between the 2 groups; heterogeneity was most frequent in group 1 (27 of 56, 48.2%) and rim enhancement was dominant in group 2 (10 of 14, 71.4%). In group 1, the gene sets related to mammary gland development were overexpressed whereas the gene sets related to mitotic cell division were overexpressed in group 2. CONCLUSION: We identified intuitive imaging features of breast MRI associated with distinct gene expression profiles using the standard imaging variables of BI-RADS. The internal enhancement pattern on MRI might reflect specific gene expression profiles of breast cancers, which can be recognized by visual distinction. |
format | Online Article Text |
id | pubmed-5507787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-55077872017-07-13 Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon Kim, Ga Ram Ku, You Jin Cho, Soon Gu Kim, Sei Joong Min, Byung Soh Ann Surg Treat Res Original Article PURPOSE: To evaluate whether the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon could reflect the genomic information of breast cancers and to suggest intuitive imaging features as biomarkers. METHODS: Matched breast MRI data from The Cancer Imaging Archive and gene expression profile from The Cancer Genome Atlas of 70 invasive breast cancers were analyzed. Magnetic resonance images were reviewed according to the BI-RADS MRI lexicon of mass morphology. The cancers were divided into 2 groups of gene clustering by gene set enrichment an alysis. Clinicopathologic and imaging characteristics were compared between the 2 groups. RESULTS: The luminal subtype was predominant in the group 1 gene set and the triple-negative subtype was predominant in the group 2 gene set (55 of 56, 98.2% vs. 9 of 14, 64.3%). Internal enhancement descriptors were different between the 2 groups; heterogeneity was most frequent in group 1 (27 of 56, 48.2%) and rim enhancement was dominant in group 2 (10 of 14, 71.4%). In group 1, the gene sets related to mammary gland development were overexpressed whereas the gene sets related to mitotic cell division were overexpressed in group 2. CONCLUSION: We identified intuitive imaging features of breast MRI associated with distinct gene expression profiles using the standard imaging variables of BI-RADS. The internal enhancement pattern on MRI might reflect specific gene expression profiles of breast cancers, which can be recognized by visual distinction. The Korean Surgical Society 2017-07 2017-06-26 /pmc/articles/PMC5507787/ /pubmed/28706887 http://dx.doi.org/10.4174/astr.2017.93.1.18 Text en Copyright © 2017, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Ga Ram Ku, You Jin Cho, Soon Gu Kim, Sei Joong Min, Byung Soh Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title | Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title_full | Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title_fullStr | Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title_full_unstemmed | Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title_short | Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon |
title_sort | associations between gene expression profiles of invasive breast cancer and breast imaging reporting and data system mri lexicon |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507787/ https://www.ncbi.nlm.nih.gov/pubmed/28706887 http://dx.doi.org/10.4174/astr.2017.93.1.18 |
work_keys_str_mv | AT kimgaram associationsbetweengeneexpressionprofilesofinvasivebreastcancerandbreastimagingreportinganddatasystemmrilexicon AT kuyoujin associationsbetweengeneexpressionprofilesofinvasivebreastcancerandbreastimagingreportinganddatasystemmrilexicon AT chosoongu associationsbetweengeneexpressionprofilesofinvasivebreastcancerandbreastimagingreportinganddatasystemmrilexicon AT kimseijoong associationsbetweengeneexpressionprofilesofinvasivebreastcancerandbreastimagingreportinganddatasystemmrilexicon AT minbyungsoh associationsbetweengeneexpressionprofilesofinvasivebreastcancerandbreastimagingreportinganddatasystemmrilexicon |