Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Xin, Khan, Afsar, Song, Da, Dai, Zhi, Liu, Ya-Ping, Yu, Hao-Fei, Wang, Bei, Zhu, Pei-Feng, Ding, Cai-Feng, Zhao, Xu-Dong, Wang, Yi-Fen, Luo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507811/
https://www.ncbi.nlm.nih.gov/pubmed/28620872
http://dx.doi.org/10.1007/s13659-017-0137-7
Descripción
Sumario:Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3(#) and GITC-18(#)), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0137-7) contains supplementary material, which is available to authorized users.

Ejemplares similares