Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

ABSTRACT: Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and ele...

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Detalles Bibliográficos
Autores principales: Qin, Xu-Jie, Shu, Tong, Yu, Qian, Yan, Huan, Ni, Wei, An, Lin-Kun, Li, Pan-Pan, Zhi, Yin-E, Khan, Afsar, Liu, Hai-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507812/
https://www.ncbi.nlm.nih.gov/pubmed/28620873
http://dx.doi.org/10.1007/s13659-017-0138-6
Descripción
Sumario:ABSTRACT: Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1–3 exhibited cytotoxicity against HCT116 cells with IC(50) values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively. GRAPHICAL ABSTRACT: Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0138-6) contains supplementary material, which is available to authorized users.

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