Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

ABSTRACT: Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and ele...

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Autores principales: Qin, Xu-Jie, Shu, Tong, Yu, Qian, Yan, Huan, Ni, Wei, An, Lin-Kun, Li, Pan-Pan, Zhi, Yin-E, Khan, Afsar, Liu, Hai-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507812/
https://www.ncbi.nlm.nih.gov/pubmed/28620873
http://dx.doi.org/10.1007/s13659-017-0138-6
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author Qin, Xu-Jie
Shu, Tong
Yu, Qian
Yan, Huan
Ni, Wei
An, Lin-Kun
Li, Pan-Pan
Zhi, Yin-E
Khan, Afsar
Liu, Hai-Yang
author_facet Qin, Xu-Jie
Shu, Tong
Yu, Qian
Yan, Huan
Ni, Wei
An, Lin-Kun
Li, Pan-Pan
Zhi, Yin-E
Khan, Afsar
Liu, Hai-Yang
author_sort Qin, Xu-Jie
collection PubMed
description ABSTRACT: Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1–3 exhibited cytotoxicity against HCT116 cells with IC(50) values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively. GRAPHICAL ABSTRACT: Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0138-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-55078122017-07-27 Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus Qin, Xu-Jie Shu, Tong Yu, Qian Yan, Huan Ni, Wei An, Lin-Kun Li, Pan-Pan Zhi, Yin-E Khan, Afsar Liu, Hai-Yang Nat Prod Bioprospect Original Article ABSTRACT: Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1–3 exhibited cytotoxicity against HCT116 cells with IC(50) values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively. GRAPHICAL ABSTRACT: Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-017-0138-6) contains supplementary material, which is available to authorized users. Springer Singapore 2017-06-15 /pmc/articles/PMC5507812/ /pubmed/28620873 http://dx.doi.org/10.1007/s13659-017-0138-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Qin, Xu-Jie
Shu, Tong
Yu, Qian
Yan, Huan
Ni, Wei
An, Lin-Kun
Li, Pan-Pan
Zhi, Yin-E
Khan, Afsar
Liu, Hai-Yang
Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title_full Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title_fullStr Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title_full_unstemmed Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title_short Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
title_sort cytotoxic acylphloroglucinol derivatives from callistemon salignus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507812/
https://www.ncbi.nlm.nih.gov/pubmed/28620873
http://dx.doi.org/10.1007/s13659-017-0138-6
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