CaMK II γ down regulation protects dorsal root ganglion neurons from ropivacaine hydrochloride neurotoxicity

T-type calcium channels are intimately involved in the local anesthetics neurotoxicity. Does CaMKIIγ regulate T-type calcium currents in local anesthetics neurotoxicity? This study generated pAd-CaMKIIγ and pAd-shRNA adenovirus vectors to up- and down-regulate CaMKIIγ mRNA expression in dorsal root...

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Detalles Bibliográficos
Autores principales: Wen, Xian-Jie, Li, Xiao-hong, Li, Heng, Liang, Hua, Yang, Chen-Xiang, Wang, Han-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507888/
https://www.ncbi.nlm.nih.gov/pubmed/28701796
http://dx.doi.org/10.1038/s41598-017-05678-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507888/
https://www.ncbi.nlm.nih.gov/pubmed/28701796
http://dx.doi.org/10.1038/s41598-017-05678-2

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