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Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The two major isoforms of the oncogenic Bcr–Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p190 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein inter...

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Detalles Bibliográficos
Autores principales:	Reckel, S, Hamelin, R, Georgeon, S, Armand, F, Jolliet, Q, Chiappe, D, Moniatte, M, Hantschel, O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508078/ https://www.ncbi.nlm.nih.gov/pubmed/28111465 http://dx.doi.org/10.1038/leu.2017.36

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