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Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

Comprehensive studies have shown that DNA methylation plays vital roles in both loss of pluripotency and governance of the transcriptome during embryogenesis and subsequent developmental processes. Aberrant DNA methylation patterns have been widely observed in tumorigenesis, ageing and neurodegenera...

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Detalles Bibliográficos
Autores principales:	Lei, Yong, Zhang, Xiaotian, Su, Jianzhong, Jeong, Mira, Gundry, Michael C., Huang, Yung-Hsin, Zhou, Yubin, Li, Wei, Goodell, Margaret A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508226/ https://www.ncbi.nlm.nih.gov/pubmed/28695892 http://dx.doi.org/10.1038/ncomms16026

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