Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen i...

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Autores principales: Xu, Zhipeng, Xu, Lei, Li, Wei, Jin, Xin, Song, Xian, Chen, Xiaojun, Zhu, Jifeng, Zhou, Sha, Li, Yong, Zhang, Weiwei, Dong, Xiaoxiao, Yang, Xiaowei, Liu, Feng, Bai, Hui, Chen, Qi, Su, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508227/
https://www.ncbi.nlm.nih.gov/pubmed/28695899
http://dx.doi.org/10.1038/ncomms16035
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author Xu, Zhipeng
Xu, Lei
Li, Wei
Jin, Xin
Song, Xian
Chen, Xiaojun
Zhu, Jifeng
Zhou, Sha
Li, Yong
Zhang, Weiwei
Dong, Xiaoxiao
Yang, Xiaowei
Liu, Feng
Bai, Hui
Chen, Qi
Su, Chuan
author_facet Xu, Zhipeng
Xu, Lei
Li, Wei
Jin, Xin
Song, Xian
Chen, Xiaojun
Zhu, Jifeng
Zhou, Sha
Li, Yong
Zhang, Weiwei
Dong, Xiaoxiao
Yang, Xiaowei
Liu, Feng
Bai, Hui
Chen, Qi
Su, Chuan
author_sort Xu, Zhipeng
collection PubMed
description The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.
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spelling pubmed-55082272017-07-17 Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection Xu, Zhipeng Xu, Lei Li, Wei Jin, Xin Song, Xian Chen, Xiaojun Zhu, Jifeng Zhou, Sha Li, Yong Zhang, Weiwei Dong, Xiaoxiao Yang, Xiaowei Liu, Feng Bai, Hui Chen, Qi Su, Chuan Nat Commun Article The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses. Nature Publishing Group 2017-07-11 /pmc/articles/PMC5508227/ /pubmed/28695899 http://dx.doi.org/10.1038/ncomms16035 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xu, Zhipeng
Xu, Lei
Li, Wei
Jin, Xin
Song, Xian
Chen, Xiaojun
Zhu, Jifeng
Zhou, Sha
Li, Yong
Zhang, Weiwei
Dong, Xiaoxiao
Yang, Xiaowei
Liu, Feng
Bai, Hui
Chen, Qi
Su, Chuan
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_full Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_fullStr Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_full_unstemmed Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_short Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_sort innate scavenger receptor-a regulates adaptive t helper cell responses to pathogen infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508227/
https://www.ncbi.nlm.nih.gov/pubmed/28695899
http://dx.doi.org/10.1038/ncomms16035
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