Cargando…

Potent Therapeutic Activity Against Peritoneal Dissemination and Malignant Ascites by the Novel Anti-Folate Receptor Alpha Antibody KHK2805()

Many ovarian cancer patients often show peritoneal metastasis with malignant ascites. However, unmet medical needs remain regarding controlling these symptoms after tumors become resistant to chemotherapies. We developed KHK2805, a novel anti-folate receptor α (FOLR1) humanized antibody with enhance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ando, Munetoshi, Nagata, Keiko, Nihira, Kaito, Suzuki, Yui, Kanda, Yutaka, Adachi, Maiko, Kubota, Tsuguo, Kameyama, Naoya, Nakano, Mariko, Ando, Hiroshi, Yamano, Kazuya, Ishii, Toshihiko, Nakai, Ryuichiro, Nakamura, Kazuyasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2017
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508476/ https://www.ncbi.nlm.nih.gov/pubmed/28710915 http://dx.doi.org/10.1016/j.tranon.2017.06.007

Ejemplares similares

2805. Kinetics of Anti-Zika Virus (ZIKV) Antibodies after Acute Infection in Pregnant Women
por: Carpentier, Mathieu, et al.
Publicado: (2019)

Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase ( Khk)
por: Chabbert, Christophe D., et al.
Publicado: (2019)

KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid
por: Velázquez, Ana Magdalena, et al.
Publicado: (2022)

2805. Extended-Infusion versus Intermittent-Infusion Piperacillin/tazobactam for High Minimum Inhibitory Concentration Pseudomonas aeruginosa Infections
por: Shifko, Carlee R, et al.
Publicado: (2023)

Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK)
por: García-Arroyo, Fernando E., et al.
Publicado: (2023)

Adherence to oral therapies among patients with renal cell carcinoma: Post hoc analysis of the ECOG‐ACRIN E2805 trial
por: Murphy, Caitlin C., et al.
Publicado: (2021)

OR2805 Plasma Sodium Increase Is Associated With An Increase In Bone Formation In Outpatients With Chronic SIAD—A Predefined Secondary Analysis Of The SANDx Trial
por: Monnerat, Sophie, et al.
Publicado: (2023)

Impact of Genetic Polymorphisms of SLC2A2, SLC2A5, and KHK on Metabolic Phenotypes in Hypertensive Individuals
por: Le, MyPhuong T., et al.
Publicado: (2013)

Phase I randomized study of KHK4083, an anti‐OX40 monoclonal antibody, in patients with mild to moderate plaque psoriasis
por: Papp, K.A., et al.
Publicado: (2017)

A novel mouse model of cutaneous T‐cell lymphoma revealed the combined effect of mogamulizumab with psoralen and ultraviolet a therapy
por: Nakahashi, Keiko, et al.
Publicado: (2022)

Differential Alterations of Dihydrofolate Reductase Gene in Human Leukemia Cell Lines Made Resistant to Various Folate Analogues
por: Miyachi, Hayato, et al.
Publicado: (1993)

Randomized, Ascending Dose, Phase 2 Study of KHK4083, an Anti-OX40 Monoclonal Antibody, in Moderately Active Ulcerative Colitis
por: Kierkus, Jaroslaw, et al.
Publicado: (2020)

Corrigendum to: Randomized, Ascending Dose, Phase 2 Study of KHK4083, an Anti-OX40 Monoclonal Antibody, in Moderately Active Ulcerative Colitis
por: Kierkus, Jaroslaw, et al.
Publicado: (2020)

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
por: Park, Se-Hyung, et al.
Publicado: (2023)

Guideline adherence in the use of coronary angiography in patients presenting at the emergency department without myocardial infarction – Results from the German ENLIGHT-KHK project()
por: Wein, Bastian, et al.
Publicado: (2023)

Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study
por: Uchida, Yasue, et al.
Publicado: (2011)

A case report: a heterozygous deletion (2791_2805 del) in exon 18 of the filamin C gene causing filamin C-related myofibrillar myopathies in a Chinese family
por: Miao, Jing, et al.
Publicado: (2018)

Cytotoxicity of Trimetrexate against Antifolate‐resistant Human T‐Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate
por: Miyachi, Hayato, et al.
Publicado: (1997)

Weaning from concentrated ascites reinfusion therapy for refractory ascites by SGLT2 inhibitor
por: Miyamoto, Yasunori, et al.
Publicado: (2021)

A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro
por: Kawata, Takehisa, et al.
Publicado: (2018)

Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
por: Nishio, Kazuko, et al.
Publicado: (2008)

Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002–2016
por: Ando, Mariko, et al.
Publicado: (2018)

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin
por: Kameyama, Kazuhisa, et al.
Publicado: (2017)

An inhibition of p62/SQSTM1 caused autophagic cell death of several human carcinoma cells
por: Nihira, Kaito, et al.
Publicado: (2014)

Hand-assisted laparoscopic Hassab’s procedure for esophagogastric varices with portal hypertension
por: Kobayashi, Takashi, et al.
Publicado: (2017)

Ascitic Fluid Analysis in the Differential Diagnosis of Ascites: Focus on Cirrhotic Ascites
por: Huang, Lin-Lin, et al.
Publicado: (2014)

Ascites, refractory ascites and hyponatremia in cirrhosis
por: Fortune, Brett, et al.
Publicado: (2017)

Chylous Ascites Due to Hyperthyroidism and Heart Failure
por: Uchihara, Masaki, et al.
Publicado: (2021)

Comment on ‘Ascitic Fluid Analysis in the Differential Diagnosis of Ascites: Focus on Cirrhotic Ascites’
por: Ahmed, Furqan
Publicado: (2017)

Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-controlled, dose-finding study
por: Akizawa, Tadao, et al.
Publicado: (2018)

Ascites
Publicado: (1854)

Psychometric properties of the self-rating organization scale with adult samples
por: Takeda, Toshinobu, et al.
Publicado: (2016)

Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
por: Morita, Tomohiro, et al.
Publicado: (2019)

Ascites—V: The Differential Diagnosis of the Cause of Ascites
Publicado: (1909)

Ascites Index – an attempt to objectify the assessment of ascites
por: Szkodziak, Piotr, et al.
Publicado: (2018)

Discovery of solabiose phosphorylase and its application for enzymatic synthesis of solabiose from sucrose and lactose
por: Saburi, Wataru, et al.
Publicado: (2022)

Hematopoietic Stem Cell Transplantation From a Related Donor with Human Leukocyte Antigen 1-Antigen Mismatch in the Graft-Versus-Host Direction Using Low-dose Anti-thymocyte Globulin
por: Kanda, Junya, et al.
Publicado: (2020)

A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis
por: Furihata, Kenichi, et al.
Publicado: (2021)

Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats
por: Kim, Hye Won, et al.
Publicado: (2011)

Management of Cirrhotic Ascites under the Add-on Administration of Tolvaptan
por: Adachi, Takuya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n23d83e3aos6gko6u1d2sprlua