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Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome
BACKGROUND: Bloodstream infections (BSIs) are associated with high morbidity and mortality worldwide. However their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. Systematic data from Vietnam are scarce. Here we present aetiologic...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508750/ https://www.ncbi.nlm.nih.gov/pubmed/28701159 http://dx.doi.org/10.1186/s12879-017-2582-7 |
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author | Dat, Vu Quoc Vu, Hieu Ngoc Nguyen The, Hung Nguyen, Hoa Thi Hoang, Long Bao Vu Tien Viet, Dung Bui, Chi Linh Van Nguyen, Kinh Nguyen, Trung Vu Trinh, Dao Tuyet Torre, Alessandro van Doorn, H. Rogier Nadjm, Behzad Wertheim, Heiman F.L. |
author_facet | Dat, Vu Quoc Vu, Hieu Ngoc Nguyen The, Hung Nguyen, Hoa Thi Hoang, Long Bao Vu Tien Viet, Dung Bui, Chi Linh Van Nguyen, Kinh Nguyen, Trung Vu Trinh, Dao Tuyet Torre, Alessandro van Doorn, H. Rogier Nadjm, Behzad Wertheim, Heiman F.L. |
author_sort | Dat, Vu Quoc |
collection | PubMed |
description | BACKGROUND: Bloodstream infections (BSIs) are associated with high morbidity and mortality worldwide. However their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. Systematic data from Vietnam are scarce. Here we present aetiologic data on BSI in adults admitted to a large tertiary referral hospital for infectious diseases in Hanoi, Vietnam. METHODS: A retrospective study was conducted at the National Hospital for Tropical Diseases between January 2011 and December 2013. Cases of BSI were determined from records in the microbiology department. Case records were obtained where possible and clinical findings, treatment and outcome were recorded. BSI were classified as community acquired if the blood sample was drawn ≤48 h after hospitalization or hospital acquired if >48 h. RESULTS: A total of 738 patients with BSI were included for microbiological analysis. The predominant pathogens were: Klebsiella pneumoniae (17.5%), Escherichia coli (17.3%), Staphylococcus aureus (14.9%), Stenotrophomonas maltophilia (9.6%) and Streptococcus suis (7.6%). The overall proportion of extended spectrum beta-lactamase (ESBL) production among Enterobacteriaceae was 25.1% (67/267 isolates) and of methicillin-resistance in S. aureus (MRSA) 37% (40/108). Clinical data was retrieved for 477 (64.6%) patients; median age was 48 years (IQR 36–60) with 27.7% female. The overall case fatality rate was 28.9% and the highest case fatality was associated with Enterobacteriaceae BSI (34.7%) which accounted for 61.6% of all BSI fatalities. CONCLUSIONS: Enterobacteriaceae (predominantly K. pneumoniae and E. coli) are the most common cause of both community and hospital acquired bloodstream infections in a tertiary referral clinic in northern Vietnam. |
format | Online Article Text |
id | pubmed-5508750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55087502017-07-17 Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome Dat, Vu Quoc Vu, Hieu Ngoc Nguyen The, Hung Nguyen, Hoa Thi Hoang, Long Bao Vu Tien Viet, Dung Bui, Chi Linh Van Nguyen, Kinh Nguyen, Trung Vu Trinh, Dao Tuyet Torre, Alessandro van Doorn, H. Rogier Nadjm, Behzad Wertheim, Heiman F.L. BMC Infect Dis Research Article BACKGROUND: Bloodstream infections (BSIs) are associated with high morbidity and mortality worldwide. However their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. Systematic data from Vietnam are scarce. Here we present aetiologic data on BSI in adults admitted to a large tertiary referral hospital for infectious diseases in Hanoi, Vietnam. METHODS: A retrospective study was conducted at the National Hospital for Tropical Diseases between January 2011 and December 2013. Cases of BSI were determined from records in the microbiology department. Case records were obtained where possible and clinical findings, treatment and outcome were recorded. BSI were classified as community acquired if the blood sample was drawn ≤48 h after hospitalization or hospital acquired if >48 h. RESULTS: A total of 738 patients with BSI were included for microbiological analysis. The predominant pathogens were: Klebsiella pneumoniae (17.5%), Escherichia coli (17.3%), Staphylococcus aureus (14.9%), Stenotrophomonas maltophilia (9.6%) and Streptococcus suis (7.6%). The overall proportion of extended spectrum beta-lactamase (ESBL) production among Enterobacteriaceae was 25.1% (67/267 isolates) and of methicillin-resistance in S. aureus (MRSA) 37% (40/108). Clinical data was retrieved for 477 (64.6%) patients; median age was 48 years (IQR 36–60) with 27.7% female. The overall case fatality rate was 28.9% and the highest case fatality was associated with Enterobacteriaceae BSI (34.7%) which accounted for 61.6% of all BSI fatalities. CONCLUSIONS: Enterobacteriaceae (predominantly K. pneumoniae and E. coli) are the most common cause of both community and hospital acquired bloodstream infections in a tertiary referral clinic in northern Vietnam. BioMed Central 2017-07-12 /pmc/articles/PMC5508750/ /pubmed/28701159 http://dx.doi.org/10.1186/s12879-017-2582-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Dat, Vu Quoc Vu, Hieu Ngoc Nguyen The, Hung Nguyen, Hoa Thi Hoang, Long Bao Vu Tien Viet, Dung Bui, Chi Linh Van Nguyen, Kinh Nguyen, Trung Vu Trinh, Dao Tuyet Torre, Alessandro van Doorn, H. Rogier Nadjm, Behzad Wertheim, Heiman F.L. Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title | Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title_full | Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title_fullStr | Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title_full_unstemmed | Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title_short | Bacterial bloodstream infections in a tertiary infectious diseases hospital in Northern Vietnam: aetiology, drug resistance, and treatment outcome |
title_sort | bacterial bloodstream infections in a tertiary infectious diseases hospital in northern vietnam: aetiology, drug resistance, and treatment outcome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508750/ https://www.ncbi.nlm.nih.gov/pubmed/28701159 http://dx.doi.org/10.1186/s12879-017-2582-7 |
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