Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first rep...

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Autores principales: Murkey, Jamie A., Chew, Kara W., Carlson, Margrit, Shannon, Chelsea L., Sirohi, Deepika, Sample, Hannah A., Wilson, Michael R., Vespa, Paul, Humphries, Romney M., Miller, Steve, Klausner, Jeffrey D., Chiu, Charles Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508774/
https://www.ncbi.nlm.nih.gov/pubmed/28721353
http://dx.doi.org/10.1093/ofid/ofx121
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author Murkey, Jamie A.
Chew, Kara W.
Carlson, Margrit
Shannon, Chelsea L.
Sirohi, Deepika
Sample, Hannah A.
Wilson, Michael R.
Vespa, Paul
Humphries, Romney M.
Miller, Steve
Klausner, Jeffrey D.
Chiu, Charles Y.
author_facet Murkey, Jamie A.
Chew, Kara W.
Carlson, Margrit
Shannon, Chelsea L.
Sirohi, Deepika
Sample, Hannah A.
Wilson, Michael R.
Vespa, Paul
Humphries, Romney M.
Miller, Steve
Klausner, Jeffrey D.
Chiu, Charles Y.
author_sort Murkey, Jamie A.
collection PubMed
description Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.
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spelling pubmed-55087742017-07-18 Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing Murkey, Jamie A. Chew, Kara W. Carlson, Margrit Shannon, Chelsea L. Sirohi, Deepika Sample, Hannah A. Wilson, Michael R. Vespa, Paul Humphries, Romney M. Miller, Steve Klausner, Jeffrey D. Chiu, Charles Y. Open Forum Infect Dis Brief Report Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation. Oxford University Press 2017-06-13 /pmc/articles/PMC5508774/ /pubmed/28721353 http://dx.doi.org/10.1093/ofid/ofx121 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Murkey, Jamie A.
Chew, Kara W.
Carlson, Margrit
Shannon, Chelsea L.
Sirohi, Deepika
Sample, Hannah A.
Wilson, Michael R.
Vespa, Paul
Humphries, Romney M.
Miller, Steve
Klausner, Jeffrey D.
Chiu, Charles Y.
Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title_full Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title_fullStr Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title_full_unstemmed Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title_short Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
title_sort hepatitis e virus–associated meningoencephalitis in a lung transplant recipient diagnosed by clinical metagenomic sequencing
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508774/
https://www.ncbi.nlm.nih.gov/pubmed/28721353
http://dx.doi.org/10.1093/ofid/ofx121
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