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Circadian dysregulation in Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of s...

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Detalles Bibliográficos
Autores principales: Videnovic, Aleksandar, Golombek, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509072/
https://www.ncbi.nlm.nih.gov/pubmed/28713867
http://dx.doi.org/10.1016/j.nbscr.2016.11.001
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author Videnovic, Aleksandar
Golombek, Diego
author_facet Videnovic, Aleksandar
Golombek, Diego
author_sort Videnovic, Aleksandar
collection PubMed
description Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD.
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spelling pubmed-55090722018-01-01 Circadian dysregulation in Parkinson's disease Videnovic, Aleksandar Golombek, Diego Neurobiol Sleep Circadian Rhythms Article Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD. Elsevier 2016-11-12 /pmc/articles/PMC5509072/ /pubmed/28713867 http://dx.doi.org/10.1016/j.nbscr.2016.11.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Videnovic, Aleksandar
Golombek, Diego
Circadian dysregulation in Parkinson's disease
title Circadian dysregulation in Parkinson's disease
title_full Circadian dysregulation in Parkinson's disease
title_fullStr Circadian dysregulation in Parkinson's disease
title_full_unstemmed Circadian dysregulation in Parkinson's disease
title_short Circadian dysregulation in Parkinson's disease
title_sort circadian dysregulation in parkinson's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509072/
https://www.ncbi.nlm.nih.gov/pubmed/28713867
http://dx.doi.org/10.1016/j.nbscr.2016.11.001
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