Cargando…
Circadian dysregulation in Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of s...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509072/ https://www.ncbi.nlm.nih.gov/pubmed/28713867 http://dx.doi.org/10.1016/j.nbscr.2016.11.001 |
_version_ | 1783249957116968960 |
---|---|
author | Videnovic, Aleksandar Golombek, Diego |
author_facet | Videnovic, Aleksandar Golombek, Diego |
author_sort | Videnovic, Aleksandar |
collection | PubMed |
description | Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD. |
format | Online Article Text |
id | pubmed-5509072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-55090722018-01-01 Circadian dysregulation in Parkinson's disease Videnovic, Aleksandar Golombek, Diego Neurobiol Sleep Circadian Rhythms Article Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD. Elsevier 2016-11-12 /pmc/articles/PMC5509072/ /pubmed/28713867 http://dx.doi.org/10.1016/j.nbscr.2016.11.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Videnovic, Aleksandar Golombek, Diego Circadian dysregulation in Parkinson's disease |
title | Circadian dysregulation in Parkinson's disease |
title_full | Circadian dysregulation in Parkinson's disease |
title_fullStr | Circadian dysregulation in Parkinson's disease |
title_full_unstemmed | Circadian dysregulation in Parkinson's disease |
title_short | Circadian dysregulation in Parkinson's disease |
title_sort | circadian dysregulation in parkinson's disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509072/ https://www.ncbi.nlm.nih.gov/pubmed/28713867 http://dx.doi.org/10.1016/j.nbscr.2016.11.001 |
work_keys_str_mv | AT videnovicaleksandar circadiandysregulationinparkinsonsdisease AT golombekdiego circadiandysregulationinparkinsonsdisease |