Impact of Sjogren's syndrome on Parkinson’s disease: A nationwide case-control study

OBJECTIVE: To investigate whether Sjogren’s syndrome would have an influence on the development of Parkinson’s disease. METHODS: A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson’s disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson’s disease in association with Sjogren’s syndrome by using adjusted odds ratios. RESULTS: A total of 143 Parkinson’s disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren’s syndrome (p < 0.001). The crude odds ratio for Parkinson’s disease among subjects with Sjogren’s syndrome was 1.56 (95% CI 1.30–1.86; p < 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson’s disease, Sjogren’s syndrome was found to be significantly associated with the risk of Parkinson’s disease with an odds ratio of 1.37 (95% CI 1.15–1.65; p < 0.01). CONCLUSION: This study preliminarily proposed that Sjogren’s syndrome was significant associated with an increased risk of Parkinson’s disease.