In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells

Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor. Our aim is to assess whether this combination results in metabolic changes that are...

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Detalles Bibliográficos
Autores principales: Al-Saffar, Nada M. S., Agliano, Alice, Marshall, Lynley V., Jackson, L. Elizabeth, Balarajah, Geetha, Sidhu, Jasmin, Clarke, Paul A., Jones, Chris, Workman, Paul, Pearson, Andrew D. J., Leach, Martin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509135/
https://www.ncbi.nlm.nih.gov/pubmed/28704425
http://dx.doi.org/10.1371/journal.pone.0180263

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