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Generation of an artificial human B cell line test system using Transpo-mAb(TM) technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins
The antigen-specific targeting of autoreactive B cells via their unique B cell receptors (BCRs) is a novel and promising alternative to the systemic suppression of humoral immunity. We generated and characterized cytolytic fusion proteins based on an existing immunotoxin comprising tetanus toxoid fr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509223/ https://www.ncbi.nlm.nih.gov/pubmed/28704435 http://dx.doi.org/10.1371/journal.pone.0180305 |