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Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates

Integral membrane proteins fold inefficiently and are susceptible to turnover via the endoplasmic reticulum–associated degradation (ERAD) pathway. During ERAD, misfolded proteins are recognized by molecular chaperones, polyubiquitinated, and retrotranslocated to the cytoplasm for proteasomal degrada...

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Detalles Bibliográficos
Autores principales:	Guerriero, Christopher J., Reutter, Karl-Richard, Augustine, Andrew A., Preston, G. Michael, Weiberth, Kurt F., Mackie, Timothy D., Cleveland-Rubeor, Hillary C., Bethel, Neville P., Callenberg, Keith M., Nakatsukasa, Kunio, Grabe, Michael, Brodsky, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509421/ https://www.ncbi.nlm.nih.gov/pubmed/28539401 http://dx.doi.org/10.1091/mbc.E17-03-0184

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