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Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes

The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing >50% of the genome,...

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Detalles Bibliográficos
Autores principales:	Bushell, Ellen, Gomes, Ana Rita, Sanderson, Theo, Anar, Burcu, Girling, Gareth, Herd, Colin, Metcalf, Tom, Modrzynska, Katarzyna, Schwach, Frank, Martin, Rowena E., Mather, Michael W., McFadden, Geoffrey I., Parts, Leopold, Rutledge, Gavin G., Vaidya, Akhil B., Wengelnik, Kai, Rayner, Julian C., Billker, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509546/ https://www.ncbi.nlm.nih.gov/pubmed/28708996 http://dx.doi.org/10.1016/j.cell.2017.06.030

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