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Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats

[Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divi...

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Autores principales: Matsumoto, Tomohiro, Ono, Takeya, Ishikura, Hideki, Aihara, Kazuki, Sato, Yuta, Tasaka, Atsushi, Umei, Namiko, Tsumiyama, Wakako, Oki, Sadaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society of Physical Therapy Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509589/
https://www.ncbi.nlm.nih.gov/pubmed/28744045
http://dx.doi.org/10.1589/jpts.29.1192
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author Matsumoto, Tomohiro
Ono, Takeya
Ishikura, Hideki
Aihara, Kazuki
Sato, Yuta
Tasaka, Atsushi
Umei, Namiko
Tsumiyama, Wakako
Oki, Sadaaki
author_facet Matsumoto, Tomohiro
Ono, Takeya
Ishikura, Hideki
Aihara, Kazuki
Sato, Yuta
Tasaka, Atsushi
Umei, Namiko
Tsumiyama, Wakako
Oki, Sadaaki
author_sort Matsumoto, Tomohiro
collection PubMed
description [Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divided into 4 groups as follows: Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7). This study was conducted for 1-week. Ankle joint range of motion and positive areas of collagen using fluorescent stain were analyzed. [Results] Ankle joint range of motion in JF + HU showed an increase compared to that of JF. Positive areas of Type I collagen in JF+HU showed an increase as compared with that of JF. [Conclusion] The results of this study suggested that the difference in a contracture caused by only joint immobilization and by a combination of joint immobilization and hindlimb unloading were significantly associated with Type I collagen.
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spelling pubmed-55095892017-07-25 Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats Matsumoto, Tomohiro Ono, Takeya Ishikura, Hideki Aihara, Kazuki Sato, Yuta Tasaka, Atsushi Umei, Namiko Tsumiyama, Wakako Oki, Sadaaki J Phys Ther Sci Original Article [Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divided into 4 groups as follows: Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7). This study was conducted for 1-week. Ankle joint range of motion and positive areas of collagen using fluorescent stain were analyzed. [Results] Ankle joint range of motion in JF + HU showed an increase compared to that of JF. Positive areas of Type I collagen in JF+HU showed an increase as compared with that of JF. [Conclusion] The results of this study suggested that the difference in a contracture caused by only joint immobilization and by a combination of joint immobilization and hindlimb unloading were significantly associated with Type I collagen. The Society of Physical Therapy Science 2017-07-15 2017-07 /pmc/articles/PMC5509589/ /pubmed/28744045 http://dx.doi.org/10.1589/jpts.29.1192 Text en 2017©by the Society of Physical Therapy Science. Published by IPEC Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
Matsumoto, Tomohiro
Ono, Takeya
Ishikura, Hideki
Aihara, Kazuki
Sato, Yuta
Tasaka, Atsushi
Umei, Namiko
Tsumiyama, Wakako
Oki, Sadaaki
Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title_full Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title_fullStr Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title_full_unstemmed Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title_short Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
title_sort effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509589/
https://www.ncbi.nlm.nih.gov/pubmed/28744045
http://dx.doi.org/10.1589/jpts.29.1192
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