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Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress

Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression...

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Autores principales: Faraji, Jamshid, Soltanpour, Nabiollah, Lotfi, Hamid, Moeeini, Reza, Moharreri, Ali-Reza, Roudaki, Shabnam, Hosseini, S. Abedin, Olson, David M., Abdollahi, Ali-Akbar, Soltanpour, Nasrin, Mohajerani, Majid H., Metz, Gerlinde A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509705/
https://www.ncbi.nlm.nih.gov/pubmed/28706188
http://dx.doi.org/10.1038/s41598-017-05440-8
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author Faraji, Jamshid
Soltanpour, Nabiollah
Lotfi, Hamid
Moeeini, Reza
Moharreri, Ali-Reza
Roudaki, Shabnam
Hosseini, S. Abedin
Olson, David M.
Abdollahi, Ali-Akbar
Soltanpour, Nasrin
Mohajerani, Majid H.
Metz, Gerlinde A. S.
author_facet Faraji, Jamshid
Soltanpour, Nabiollah
Lotfi, Hamid
Moeeini, Reza
Moharreri, Ali-Reza
Roudaki, Shabnam
Hosseini, S. Abedin
Olson, David M.
Abdollahi, Ali-Akbar
Soltanpour, Nasrin
Mohajerani, Majid H.
Metz, Gerlinde A. S.
author_sort Faraji, Jamshid
collection PubMed
description Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience.
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spelling pubmed-55097052017-07-17 Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress Faraji, Jamshid Soltanpour, Nabiollah Lotfi, Hamid Moeeini, Reza Moharreri, Ali-Reza Roudaki, Shabnam Hosseini, S. Abedin Olson, David M. Abdollahi, Ali-Akbar Soltanpour, Nasrin Mohajerani, Majid H. Metz, Gerlinde A. S. Sci Rep Article Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience. Nature Publishing Group UK 2017-07-13 /pmc/articles/PMC5509705/ /pubmed/28706188 http://dx.doi.org/10.1038/s41598-017-05440-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Faraji, Jamshid
Soltanpour, Nabiollah
Lotfi, Hamid
Moeeini, Reza
Moharreri, Ali-Reza
Roudaki, Shabnam
Hosseini, S. Abedin
Olson, David M.
Abdollahi, Ali-Akbar
Soltanpour, Nasrin
Mohajerani, Majid H.
Metz, Gerlinde A. S.
Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_full Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_fullStr Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_full_unstemmed Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_short Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_sort lack of social support raises stress vulnerability in rats with a history of ancestral stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509705/
https://www.ncbi.nlm.nih.gov/pubmed/28706188
http://dx.doi.org/10.1038/s41598-017-05440-8
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