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Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509705/ https://www.ncbi.nlm.nih.gov/pubmed/28706188 http://dx.doi.org/10.1038/s41598-017-05440-8 |
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author | Faraji, Jamshid Soltanpour, Nabiollah Lotfi, Hamid Moeeini, Reza Moharreri, Ali-Reza Roudaki, Shabnam Hosseini, S. Abedin Olson, David M. Abdollahi, Ali-Akbar Soltanpour, Nasrin Mohajerani, Majid H. Metz, Gerlinde A. S. |
author_facet | Faraji, Jamshid Soltanpour, Nabiollah Lotfi, Hamid Moeeini, Reza Moharreri, Ali-Reza Roudaki, Shabnam Hosseini, S. Abedin Olson, David M. Abdollahi, Ali-Akbar Soltanpour, Nasrin Mohajerani, Majid H. Metz, Gerlinde A. S. |
author_sort | Faraji, Jamshid |
collection | PubMed |
description | Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience. |
format | Online Article Text |
id | pubmed-5509705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55097052017-07-17 Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress Faraji, Jamshid Soltanpour, Nabiollah Lotfi, Hamid Moeeini, Reza Moharreri, Ali-Reza Roudaki, Shabnam Hosseini, S. Abedin Olson, David M. Abdollahi, Ali-Akbar Soltanpour, Nasrin Mohajerani, Majid H. Metz, Gerlinde A. S. Sci Rep Article Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience. Nature Publishing Group UK 2017-07-13 /pmc/articles/PMC5509705/ /pubmed/28706188 http://dx.doi.org/10.1038/s41598-017-05440-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Faraji, Jamshid Soltanpour, Nabiollah Lotfi, Hamid Moeeini, Reza Moharreri, Ali-Reza Roudaki, Shabnam Hosseini, S. Abedin Olson, David M. Abdollahi, Ali-Akbar Soltanpour, Nasrin Mohajerani, Majid H. Metz, Gerlinde A. S. Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title | Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title_full | Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title_fullStr | Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title_full_unstemmed | Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title_short | Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress |
title_sort | lack of social support raises stress vulnerability in rats with a history of ancestral stress |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509705/ https://www.ncbi.nlm.nih.gov/pubmed/28706188 http://dx.doi.org/10.1038/s41598-017-05440-8 |
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