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Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

Enzymes sample multiple conformations during their catalytic cycles. Chemical shifts from Nuclear Magnetic Resonance (NMR) are hypersensitive to conformational changes and ensembles in solution. Phosphomannomutase/phosphoglucomutase (PMM/PGM) is a ubiquitous four-domain enzyme that catalyzes phospho...

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Detalles Bibliográficos
Autores principales:	Xu, Jia, Sarma, Akella V. S., Wei, Yirui, Beamer, Lesa J., Van Doren, Steven R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509744/ https://www.ncbi.nlm.nih.gov/pubmed/28706231 http://dx.doi.org/10.1038/s41598-017-05557-w

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