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In vitro model to study the effects of matrix stiffening on Ca(2+) handling and myofilament function in isolated adult rat cardiomyocytes

KEY POINTS: This paper describes a novel model that allows exploration of matrix‐induced cardiomyocyte adaptations independent of the passive effect of matrix rigidity on cardiomyocyte function. Detachment of adult cardiomyocytes from the matrix enables the study of matrix effects on cell shortening...

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Detalles Bibliográficos
Autores principales:	van Deel, Elza D., Najafi, Aref, Fontoura, Dulce, Valent, Erik, Goebel, Max, Kardux, Kim, Falcão‐Pires, Inês, van der Velden, Jolanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Techniques for Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509860/ https://www.ncbi.nlm.nih.gov/pubmed/28485491 http://dx.doi.org/10.1113/JP274460

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