Cargando…

In vitro model to study the effects of matrix stiffening on Ca(2+) handling and myofilament function in isolated adult rat cardiomyocytes

KEY POINTS: This paper describes a novel model that allows exploration of matrix‐induced cardiomyocyte adaptations independent of the passive effect of matrix rigidity on cardiomyocyte function. Detachment of adult cardiomyocytes from the matrix enables the study of matrix effects on cell shortening...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Deel, Elza D., Najafi, Aref, Fontoura, Dulce, Valent, Erik, Goebel, Max, Kardux, Kim, Falcão‐Pires, Inês, van der Velden, Jolanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Techniques for Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509860/ https://www.ncbi.nlm.nih.gov/pubmed/28485491 http://dx.doi.org/10.1113/JP274460

Ejemplares similares

Diastolic myofilament dysfunction in the failing human heart
por: van der Velden, Jolanda
Publicado: (2011)

Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes
por: Schuldt, Maike, et al.
Publicado: (2021)

Extracellular SPARC increases cardiomyocyte contraction during health and disease
por: Deckx, Sophie, et al.
Publicado: (2019)

Hypertrophic cardiomyopathy mutations increase myofilament Ca(2+) buffering, alter intracellular Ca(2+) handling, and stimulate Ca(2+)-dependent signaling
por: Robinson, Paul, et al.
Publicado: (2018)

Right‐ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca(2+) homeostasis and myofilament sensitivity
por: Hegemann, Niklas, et al.
Publicado: (2021)

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output
por: Helmes, Michiel, et al.
Publicado: (2016)

Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart
por: Bollen, Ilse A. E., et al.
Publicado: (2015)

End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium
por: Najafi, Aref, et al.
Publicado: (2019)

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes
por: Verkaik, Melissa, et al.
Publicado: (2018)

Transmural Heterogeneity of Myofilament Function and Sarcomeric Protein Phosphorylation in Remodeled Myocardium of Pigs with a Recent Myocardial Infarction
por: van der Velden, Jolanda, et al.
Publicado: (2011)

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
por: Wijnker, Paul J. M., et al.
Publicado: (2011)

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations
por: Sparrow, Alexander J., et al.
Publicado: (2019)

Cardiomyocyte Ca(2+) handling and structure is regulated by degree and duration of mechanical load variation
por: Ibrahim, Michael, et al.
Publicado: (2012)

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
por: Sequeira, Vasco, et al.
Publicado: (2022)

Arrhythmogenic Current Generation by Myofilament-Triggered Ca(2+) Release and Sarcomere Heterogeneity
por: Timmermann, Viviane, et al.
Publicado: (2019)

Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca(2+) Handling In Vitro
por: Mellor, Kimberley M., et al.
Publicado: (2011)

The Myofilament Lattice: Studies on Isolated Fibers : III. The effect of myofilament spacing upon tension
por: April, Ernest W., et al.
Publicado: (1973)

STIM1-dependent Ca(2+) microdomains are required for myofilament remodeling and signaling in the heart
por: Parks, Cory, et al.
Publicado: (2016)

There Goes the Neighborhood: Pathological Alterations in T-Tubule Morphology and Consequences for Cardiomyocyte Ca(2+) Handling
por: Louch, William E., et al.
Publicado: (2010)

The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening
por: Hersch, Nils, et al.
Publicado: (2013)

Why Is there a Limit to the Changes in Myofilament Ca(2+)-Sensitivity Associated with Myopathy Causing Mutations?
por: Marston, Steven B.
Publicado: (2016)

A NOTE ON THE STRUCTURE OF CRAYFISH MYOFILAMENTS
por: Peterson, R. Price
Publicado: (1963)

Myofilament function and body mass index
por: Bening, Constanze, et al.
Publicado: (2017)

Dystrophic cardiomyopathy: role of the cardiac myofilaments
por: George, Thomas G., et al.
Publicado: (2023)

Stx4 is required to regulate cardiomyocyte Ca(2+) handling during vertebrate cardiac development
por: Perl, Eliyahu, et al.
Publicado: (2022)

Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca(2+) sensitivity
por: Reda, Sherif M., et al.
Publicado: (2018)

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
por: Juni, Rio P., et al.
Publicado: (2019)

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk‐related rat model of heart failure with preserved ejection fraction
por: Miranda‐Silva, Daniela, et al.
Publicado: (2019)

Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway
por: Lertwanakarn, Tuchakorn, et al.
Publicado: (2021)

Expression of connexin 43, ion channels and Ca(2+)-handling proteins in rat pulmonary vein cardiomyocytes
por: Xiao, Yaqiong, et al.
Publicado: (2016)

REVERSIBLE DISAGGREGATION OF MYOFILAMENTS IN VERTEBRATE SMOOTH MUSCLE
por: Fay, Fredric S., et al.
Publicado: (1973)

Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes
por: Nollet, Edgar E., et al.
Publicado: (2020)

Ion Channel Impairment and Myofilament Ca(2+) Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy
por: Santini, Lorenzo, et al.
Publicado: (2021)

Maximal Ca2+-activated force and myofilament Ca2+ sensitivity in intact mammalian hearts. Differential effects of inorganic phosphate and hydrogen ions
Publicado: (1987)

MYOFILAMENTS IN SMOOTH MUSCLE OF GUINEA PIG'S TAENIA COLI
por: Nonomura, Yoshiaki
Publicado: (1968)

Increased myofilament Ca(2+) sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice
por: Fraysse, Bodvaël, et al.
Publicado: (2012)

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
por: de Boer, Martine, et al.
Publicado: (2023)

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy
por: Bollen, Ilse A. E., et al.
Publicado: (2017)

Stiffening under pressure
por: LeBrasseur, Nicole
Publicado: (2005)

Endothelial stiffening in dyslipidemia
por: Le Master, Elizabeth, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t5ubgn9t5l95abrspsofvfbui2