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RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

During replication‐coupled DNA interstrand crosslink (ICL) repair, the XPF‐ERCC1 endonuclease is required for the incisions that release, or “unhook”, ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strik...

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Detalles Bibliográficos
Autores principales:	Abdullah, Ummi B, McGouran, Joanna F, Brolih, Sanja, Ptchelkine, Denis, El‐Sagheer, Afaf H, Brown, Tom, McHugh, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510000/ https://www.ncbi.nlm.nih.gov/pubmed/28607004 http://dx.doi.org/10.15252/embj.201796664

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