Design, preparation, and selection of DNA-encoded dynamic libraries

We report a method for the preparation and selection of DNA-encoded dynamic libraries (DEDLs). The library is composed of two sets of DNA-linked small molecules that are under dynamic exchange through DNA hybridization. Addition of the protein target shifted the equilibrium, favouring the assembly o...

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Detalles Bibliográficos
Autores principales: Li, Gang, Zheng, Wenlu, Chen, Zitian, Zhou, Yu, Liu, Yu, Yang, Junrui, Huang, Yanyi, Li, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510007/
https://www.ncbi.nlm.nih.gov/pubmed/28757982
http://dx.doi.org/10.1039/c5sc02467f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510007/
https://www.ncbi.nlm.nih.gov/pubmed/28757982
http://dx.doi.org/10.1039/c5sc02467f

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