Cargando…

A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves

The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid aortic valves to determine the need for closer echocardiographic scrutiny/follow-...

Descripción completa

Detalles Bibliográficos
Autores principales: van Rensburg, Annari, Herbst, Philip, Doubell, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510443/
https://www.ncbi.nlm.nih.gov/pubmed/28515127
http://dx.doi.org/10.1530/ERP-17-0016
_version_ 1783250188449611776
author van Rensburg, Annari
Herbst, Philip
Doubell, Anton
author_facet van Rensburg, Annari
Herbst, Philip
Doubell, Anton
author_sort van Rensburg, Annari
collection PubMed
description The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid aortic valves to determine the need for closer echocardiographic scrutiny/follow-up of the mitral valve. A retrospective analysis of echocardiograms done at a referral hospital over five years was conducted in patients with bicuspid aortic valves with special attention to congenital abnormalities of the mitral valve. One hundred and forty patients with a bicuspid aortic valve were included. A congenital mitral valve abnormality was present in eight (5.7%, P = 0.01) with a parachute mitral valve in four (2.8%), an accessory mitral valve leaflet in one (0.7%), mitral valve prolapse in one, a cleft in one and the novel finding of a trileaflet mitral valve in one. Minor abnormalities included an elongated anterior mitral valve leaflet (P < 0.001), the increased incidence of physiological mitral regurgitation (P < 0.001), abnormal papillary muscles (P = 0.002) and an additional chord or tendon in the left ventricle cavity (P = 0.007). Mitral valve abnormalities occur more commonly in patients with bicuspid aortic valves than matched healthy individuals. The study confirms that abnormalities in these patients extend beyond the aorta. These abnormalities did not have a significant functional effect.
format Online
Article
Text
id pubmed-5510443
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-55104432017-07-18 A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves van Rensburg, Annari Herbst, Philip Doubell, Anton Echo Res Pract Research The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid aortic valves to determine the need for closer echocardiographic scrutiny/follow-up of the mitral valve. A retrospective analysis of echocardiograms done at a referral hospital over five years was conducted in patients with bicuspid aortic valves with special attention to congenital abnormalities of the mitral valve. One hundred and forty patients with a bicuspid aortic valve were included. A congenital mitral valve abnormality was present in eight (5.7%, P = 0.01) with a parachute mitral valve in four (2.8%), an accessory mitral valve leaflet in one (0.7%), mitral valve prolapse in one, a cleft in one and the novel finding of a trileaflet mitral valve in one. Minor abnormalities included an elongated anterior mitral valve leaflet (P < 0.001), the increased incidence of physiological mitral regurgitation (P < 0.001), abnormal papillary muscles (P = 0.002) and an additional chord or tendon in the left ventricle cavity (P = 0.007). Mitral valve abnormalities occur more commonly in patients with bicuspid aortic valves than matched healthy individuals. The study confirms that abnormalities in these patients extend beyond the aorta. These abnormalities did not have a significant functional effect. Bioscientifica Ltd 2017-05-17 /pmc/articles/PMC5510443/ /pubmed/28515127 http://dx.doi.org/10.1530/ERP-17-0016 Text en © 2017 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
van Rensburg, Annari
Herbst, Philip
Doubell, Anton
A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title_full A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title_fullStr A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title_full_unstemmed A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title_short A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
title_sort retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510443/
https://www.ncbi.nlm.nih.gov/pubmed/28515127
http://dx.doi.org/10.1530/ERP-17-0016
work_keys_str_mv AT vanrensburgannari aretrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves
AT herbstphilip aretrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves
AT doubellanton aretrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves
AT vanrensburgannari retrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves
AT herbstphilip retrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves
AT doubellanton retrospectiveanalysisofmitralvalvepathologyinthesettingofbicuspidaorticvalves