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Genetic disruption of multidrug resistance-associated protein 1 improves endothelial function and attenuates atherosclerosis in MRP1(−/−) LDLr(−/−) double knockout mice

INTRODUCTION: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitr...

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Detalles Bibliográficos
Autores principales:	Jehle, Julian, Müller, Cornelius F. H., Aksoy, Adem, Zimmer, Sebastian, Nickenig, Georg, Tiyerili, Vedat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Termedia Publishing House 2017
Materias:	Experimental Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510514/ https://www.ncbi.nlm.nih.gov/pubmed/28721160 http://dx.doi.org/10.5114/aoms.2017.68239

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