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Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 con...

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Autores principales: Gorzelak-Pabiś, Paulina, Chalubinski, Maciej, Wojdan, Katarzyna, Luczak, Emilia, Duraj, Iwona, Mozdzan, Monika, Broncel, Marlena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510518/
https://www.ncbi.nlm.nih.gov/pubmed/28721145
http://dx.doi.org/10.5114/aoms.2016.63751
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author Gorzelak-Pabiś, Paulina
Chalubinski, Maciej
Wojdan, Katarzyna
Luczak, Emilia
Duraj, Iwona
Mozdzan, Monika
Broncel, Marlena
author_facet Gorzelak-Pabiś, Paulina
Chalubinski, Maciej
Wojdan, Katarzyna
Luczak, Emilia
Duraj, Iwona
Mozdzan, Monika
Broncel, Marlena
author_sort Gorzelak-Pabiś, Paulina
collection PubMed
description INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status. MATERIAL AND METHODS: Thirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods. RESULTS: The CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01). CONCLUSIONS: These results suggest a possible association between high levels of IL-35 and CAD.
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spelling pubmed-55105182017-07-18 Increased plasma concentrations of interleukin 35 in patients with coronary artery disease Gorzelak-Pabiś, Paulina Chalubinski, Maciej Wojdan, Katarzyna Luczak, Emilia Duraj, Iwona Mozdzan, Monika Broncel, Marlena Arch Med Sci Clinical Research INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status. MATERIAL AND METHODS: Thirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods. RESULTS: The CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01). CONCLUSIONS: These results suggest a possible association between high levels of IL-35 and CAD. Termedia Publishing House 2016-11-18 2017-06 /pmc/articles/PMC5510518/ /pubmed/28721145 http://dx.doi.org/10.5114/aoms.2016.63751 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Gorzelak-Pabiś, Paulina
Chalubinski, Maciej
Wojdan, Katarzyna
Luczak, Emilia
Duraj, Iwona
Mozdzan, Monika
Broncel, Marlena
Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title_full Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title_fullStr Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title_full_unstemmed Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title_short Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
title_sort increased plasma concentrations of interleukin 35 in patients with coronary artery disease
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510518/
https://www.ncbi.nlm.nih.gov/pubmed/28721145
http://dx.doi.org/10.5114/aoms.2016.63751
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