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Increased plasma concentrations of interleukin 35 in patients with coronary artery disease
INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510518/ https://www.ncbi.nlm.nih.gov/pubmed/28721145 http://dx.doi.org/10.5114/aoms.2016.63751 |
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author | Gorzelak-Pabiś, Paulina Chalubinski, Maciej Wojdan, Katarzyna Luczak, Emilia Duraj, Iwona Mozdzan, Monika Broncel, Marlena |
author_facet | Gorzelak-Pabiś, Paulina Chalubinski, Maciej Wojdan, Katarzyna Luczak, Emilia Duraj, Iwona Mozdzan, Monika Broncel, Marlena |
author_sort | Gorzelak-Pabiś, Paulina |
collection | PubMed |
description | INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status. MATERIAL AND METHODS: Thirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods. RESULTS: The CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01). CONCLUSIONS: These results suggest a possible association between high levels of IL-35 and CAD. |
format | Online Article Text |
id | pubmed-5510518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-55105182017-07-18 Increased plasma concentrations of interleukin 35 in patients with coronary artery disease Gorzelak-Pabiś, Paulina Chalubinski, Maciej Wojdan, Katarzyna Luczak, Emilia Duraj, Iwona Mozdzan, Monika Broncel, Marlena Arch Med Sci Clinical Research INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status. MATERIAL AND METHODS: Thirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods. RESULTS: The CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01). CONCLUSIONS: These results suggest a possible association between high levels of IL-35 and CAD. Termedia Publishing House 2016-11-18 2017-06 /pmc/articles/PMC5510518/ /pubmed/28721145 http://dx.doi.org/10.5114/aoms.2016.63751 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Gorzelak-Pabiś, Paulina Chalubinski, Maciej Wojdan, Katarzyna Luczak, Emilia Duraj, Iwona Mozdzan, Monika Broncel, Marlena Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title | Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title_full | Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title_fullStr | Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title_full_unstemmed | Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title_short | Increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
title_sort | increased plasma concentrations of interleukin 35 in patients with coronary artery disease |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510518/ https://www.ncbi.nlm.nih.gov/pubmed/28721145 http://dx.doi.org/10.5114/aoms.2016.63751 |
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