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Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus
INTRODUCTION: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, lep...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510519/ https://www.ncbi.nlm.nih.gov/pubmed/28721140 http://dx.doi.org/10.5114/aoms.2016.60680 |
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author | Ismail, Mohamed M. Abdel Hamid, Tamer A. Ibrahim, Alshaymaa A. Marzouk, Huda |
author_facet | Ismail, Mohamed M. Abdel Hamid, Tamer A. Ibrahim, Alshaymaa A. Marzouk, Huda |
author_sort | Ismail, Mohamed M. |
collection | PubMed |
description | INTRODUCTION: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes. MATERIAL AND METHODS: Fifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay. RESULTS: There were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA(1c)) (p = 0.006), while other adipokines were not interrelated. CONCLUSIONS: These results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes. |
format | Online Article Text |
id | pubmed-5510519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-55105192017-07-18 Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus Ismail, Mohamed M. Abdel Hamid, Tamer A. Ibrahim, Alshaymaa A. Marzouk, Huda Arch Med Sci Clinical Research INTRODUCTION: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes. MATERIAL AND METHODS: Fifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay. RESULTS: There were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA(1c)) (p = 0.006), while other adipokines were not interrelated. CONCLUSIONS: These results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes. Termedia Publishing House 2016-06-17 2017-06 /pmc/articles/PMC5510519/ /pubmed/28721140 http://dx.doi.org/10.5114/aoms.2016.60680 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Ismail, Mohamed M. Abdel Hamid, Tamer A. Ibrahim, Alshaymaa A. Marzouk, Huda Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title | Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title_full | Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title_fullStr | Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title_full_unstemmed | Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title_short | Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus |
title_sort | serum adipokines and vitamin d levels in patients with type 1 diabetes mellitus |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510519/ https://www.ncbi.nlm.nih.gov/pubmed/28721140 http://dx.doi.org/10.5114/aoms.2016.60680 |
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