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The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into H...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Author(s).
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510751/ https://www.ncbi.nlm.nih.gov/pubmed/28514659 http://dx.doi.org/10.1016/j.celrep.2017.04.059 |
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| author | Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L. Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter |
| author_facet | Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L. Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter |
| author_sort | Hilton, Hugo G. |
| collection | PubMed |
| description | HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B(∗)46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B(∗)46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B(∗)46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B(∗)46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B(∗)46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia. |
| format | Online Article Text |
| id | pubmed-5510751 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | The Author(s). |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55107512017-07-14 The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L. Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter Cell Rep Article HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B(∗)46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B(∗)46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B(∗)46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B(∗)46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B(∗)46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia. The Author(s). 2017-05-16 2017-05-16 /pmc/articles/PMC5510751/ /pubmed/28514659 http://dx.doi.org/10.1016/j.celrep.2017.04.059 Text en © 2017 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L. Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title | The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_full | The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_fullStr | The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_full_unstemmed | The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_short | The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_sort | intergenic recombinant hla-b∗46:01 has a distinctive peptidome that includes kir2dl3 ligands |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510751/ https://www.ncbi.nlm.nih.gov/pubmed/28514659 http://dx.doi.org/10.1016/j.celrep.2017.04.059 |
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