Cargando…

Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two

Introduction: Cannabis biosynthesizes Δ(9)-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ(9)-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of THCA-A, but its clinical application may be hampered by instability. THCA-A lacks cannabimimetic effects; we...

Descripción completa

Detalles Bibliográficos
Autores principales:	McPartland, John M., MacDonald, Christa, Young, Michelle, Grant, Phillip S., Furkert, Daniel P., Glass, Michelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510775/ https://www.ncbi.nlm.nih.gov/pubmed/28861508 http://dx.doi.org/10.1089/can.2016.0032

Ejemplares similares

Mechanistic origin of partial agonism of tetrahydrocannabinol for cannabinoid receptors
por: Dutta, Soumajit, et al.
Publicado: (2022)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
por: Finlay, David B., et al.
Publicado: (2022)

The Diels‐Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC)
por: Hurrle, Thomas, et al.
Publicado: (2021)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells
por: Yang, Lei, et al.
Publicado: (2015)

Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors
por: Bhattacharyya, Sagnik, et al.
Publicado: (2017)

Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ(9)-Tetrahydrocannabinol
por: Breivogel, Chris S., et al.
Publicado: (2020)

α-Glucosidase inhibitory activity of cannabidiol, tetrahydrocannabinol and standardized cannabinoid extracts from Cannabissativa
por: Suttithumsatid, Wiwit, et al.
Publicado: (2022)

HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits
por: Roberts, Benjamin Z, et al.
Publicado: (2021)

Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study
por: Chung, Hery, et al.
Publicado: (2019)

Potential Pro-Inflammatory Effect of Vitamin E Analogs through Mitigation of Tetrahydrocannabinol (THC) Binding to the Cannabinoid 2 Receptor
por: Manandhar, Anjela, et al.
Publicado: (2022)

QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids
por: Lee, Wonyoung, et al.
Publicado: (2020)

CUMYL-4CN-BINACA Is an Efficacious and Potent Pro-Convulsant Synthetic Cannabinoid Receptor Agonist
por: Kevin, Richard C., et al.
Publicado: (2019)

Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature
por: Golombek, Patricia, et al.
Publicado: (2020)

The Leu/Val(6.51) Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ(9)-Tetrahydrocannabinol
por: Llinas del Torrent, Claudia, et al.
Publicado: (2023)

Cannabinoid 1 (CB(1)) receptor arrestin subtype‐selectivity and phosphorylation dependence
por: Manning, Jamie J., et al.
Publicado: (2022)

Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and ∆ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs
por: Schaefer, Nadine, et al.
Publicado: (2017)

Adulteration of low‐delta‐9‐tetrahydrocannabinol products with synthetic cannabinoids: Results from drug checking services
por: Monti, Manuela Carla, et al.
Publicado: (2022)

Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors
por: Finlay, David B., et al.
Publicado: (2020)

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes
por: Furkert, David, et al.
Publicado: (2021)

Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay
por: Cha, Hye Jin, et al.
Publicado: (2019)

Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro
por: Milian, Lara, et al.
Publicado: (2020)

Electrical design details /
por: McPartland, Joseph F.
Publicado: (1960)

Handbook of practical electrical design /
por: McPartland, Joseph F.
Publicado: (1999)

Obesity, the Endocannabinoid System, and Bias Arising from Pharmaceutical Sponsorship
por: McPartland, John M.
Publicado: (2009)

Cannabis Systematics at the Levels of Family, Genus, and Species
por: McPartland, John M.
Publicado: (2018)

Benefit of Tetrahydrocannabinol versus Cannabidiol for Common Palliative Care Symptoms
por: Casarett, David J., et al.
Publicado: (2019)

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB(1) and Serotonin 5-HT(2A) Receptors
por: Viñals, Xavier, et al.
Publicado: (2015)

Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2
por: Xie, Junran, et al.
Publicado: (2016)

Affinity Assays for Cannabinoids Detection: Are They Amenable to On-Site Screening?
por: Puiu, Mihaela, et al.
Publicado: (2022)

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ(8/9)-Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells
por: Soethoudt, Marjolein, et al.
Publicado: (2018)

Disruption of hippocampal synaptic transmission and long‐term potentiation by psychoactive synthetic cannabinoid ‘Spice’ compounds: comparison with Δ(9)‐tetrahydrocannabinol
por: Hoffman, Alexander F., et al.
Publicado: (2016)

Adolescent Female Cannabinoid Exposure Diminishes the Reward-Facilitating Effects of Δ(9)-Tetrahydrocannabinol and d-Amphetamine in the Adult Male Offspring
por: Pitsilis, George, et al.
Publicado: (2017)

Cannabinoid CB(2) receptor ligand profiling reveals biased signalling and off-target activity
por: Soethoudt, Marjolein, et al.
Publicado: (2017)

A classification of endangered high-THC cannabis (Cannabis sativa subsp. indica) domesticates and their wild relatives
por: McPartland, John M., et al.
Publicado: (2020)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
por: Brents, Lisa K., et al.
Publicado: (2011)

Continuous-Flow Synthesis of Δ(9)-Tetrahydrocannabinol and Δ(8)-Tetrahydrocannabinol from Cannabidiol
por: Bassetti, Benedetta, et al.
Publicado: (2023)

Anticancer Effect of New Cannabinoids Derived from Tetrahydrocannabinolic Acid on PANC-1 and AsPC-1 Human Pancreas Tumor Cells
por: Aizikovich, Alexander
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3pds61kgk58c6bsb9qu2kuk6gk