Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model

BACKGROUND: Despite considerable investigational efforts, no method to overcome the pathogenesis caused by loss of function (LoF) mutations in tumor suppressor genes has been successfully translated to the clinic. The most frequent LoF mutation in human cancers is Adenomatous polyposis coli (APC), c...

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Detalles Bibliográficos
Autores principales: Hochman, Gili, Halevi-Tobias, Karin, Kogan, Yuri, Agur, Zvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510801/
https://www.ncbi.nlm.nih.gov/pubmed/28708837
http://dx.doi.org/10.1371/journal.pone.0179888

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