Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing

Wnt/β-catenin signal transduction directs intestinal stem cell (ISC) proliferation during homeostasis. Hyperactivation of Wnt signaling initiates colorectal cancer, which most frequently results from truncation of the tumor suppressor Adenomatous polyposis coli (APC). The β-catenin-TCF transcription...

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Detalles Bibliográficos
Autores principales: Tian, Ai, Benchabane, Hassina, Wang, Zhenghan, Zimmerman, Chloe, Xin, Nan, Perochon, Jessica, Kalna, Gabriela, Sansom, Owen J., Cheng, Chao, Cordero, Julia B., Ahmed, Yashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510812/
https://www.ncbi.nlm.nih.gov/pubmed/28708826
http://dx.doi.org/10.1371/journal.pgen.1006870

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