TNF signalling drives expansion of bone marrow CD4(+) T cells responsible for HSC exhaustion in experimental visceral leishmaniasis

Visceral leishmaniasis is associated with significant changes in hematological function but the mechanisms underlying these changes are largely unknown. In contrast to naïve mice, where most long-term hematopoietic stem cells (LT-HSCs; LSK CD150(+) CD34(-) CD48(-) cells) in bone marrow (BM) are quie...

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Detalles Bibliográficos
Autores principales: Pinto, Ana Isabel, Brown, Najmeeyah, Preham, Olivier, Doehl, Johannes S. P., Ashwin, Helen, Kaye, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510901/
https://www.ncbi.nlm.nih.gov/pubmed/28671989
http://dx.doi.org/10.1371/journal.ppat.1006465

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