Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

BACKGROUND: Antipsychotic action of haloperidol is due to blockade of D(2) receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D(2) receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these re...

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Detalles Bibliográficos
Autores principales: Zastrozhin, Mikhail Sergeevich, Brodyansky, Vadim Markovich, Skryabin, Valentin Yurievich, Grishina, Elena Anatolievna, Ivashchenko, Dmitry Vladimirovich, Ryzhikova, Kristina Anatolievna, Savchenko, Ludmila Mikhaylovna, Kibitov, Alexander Olegovich, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511016/
https://www.ncbi.nlm.nih.gov/pubmed/28744152
http://dx.doi.org/10.2147/PGPM.S140700

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