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Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

L-type calcium channel Ca(V)1.2 plays an essential role in cardiac function. The gain-of-function mutations in Ca(V)1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we demonstrated that roscovitine, a cyclin-dependen...

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Detalles Bibliográficos
Autores principales:	Song, LouJin, Park, Seon-hye E., Isseroff, Yehuda, Morikawa, Kumi, Yazawa, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511105/ https://www.ncbi.nlm.nih.gov/pubmed/28648896 http://dx.doi.org/10.1016/j.stemcr.2017.05.028

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