The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial Parkinson’s disease (PD). LRRK2 protein contains several functional domains, including protein-protein interaction domains at its N- and C-termini. In this study, we analyzed the functional features attributed to...

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Detalles Bibliográficos
Autores principales: Carrion, Maria Dolores Perez, Marsicano, Silvia, Daniele, Federica, Marte, Antonella, Pischedda, Francesca, Di Cairano, Eliana, Piovesana, Ester, von Zweydorf, Felix, Kremmer, Elisabeth, Gloeckner, Christian Johannes, Onofri, Franco, Perego, Carla, Piccoli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511190/
https://www.ncbi.nlm.nih.gov/pubmed/28710481
http://dx.doi.org/10.1038/s41598-017-05760-9

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