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Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation
Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactid...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511230/ https://www.ncbi.nlm.nih.gov/pubmed/28710483 http://dx.doi.org/10.1038/s41598-017-06122-1 |
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author | Niu, Chengcheng Xu, Yan An, Senbo Zhang, Ming Hu, Yihe Wang, Long Peng, Qinghai |
author_facet | Niu, Chengcheng Xu, Yan An, Senbo Zhang, Ming Hu, Yihe Wang, Long Peng, Qinghai |
author_sort | Niu, Chengcheng |
collection | PubMed |
description | Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe(3)O(4)), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe(3)O(4)/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe(3)O(4)/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe(3)O(4)/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe(3)O(4)/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation. |
format | Online Article Text |
id | pubmed-5511230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55112302017-07-17 Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation Niu, Chengcheng Xu, Yan An, Senbo Zhang, Ming Hu, Yihe Wang, Long Peng, Qinghai Sci Rep Article Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe(3)O(4)), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe(3)O(4)/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe(3)O(4)/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe(3)O(4)/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe(3)O(4)/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation. Nature Publishing Group UK 2017-07-14 /pmc/articles/PMC5511230/ /pubmed/28710483 http://dx.doi.org/10.1038/s41598-017-06122-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Niu, Chengcheng Xu, Yan An, Senbo Zhang, Ming Hu, Yihe Wang, Long Peng, Qinghai Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title | Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title_full | Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title_fullStr | Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title_full_unstemmed | Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title_short | Near-infrared induced phase-shifted ICG/Fe(3)O(4) loaded PLGA nanoparticles for photothermal tumor ablation |
title_sort | near-infrared induced phase-shifted icg/fe(3)o(4) loaded plga nanoparticles for photothermal tumor ablation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511230/ https://www.ncbi.nlm.nih.gov/pubmed/28710483 http://dx.doi.org/10.1038/s41598-017-06122-1 |
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