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ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice

Protease-activated receptor 2 (PAR-2) plays an important role in the pathogenesis of liver fibrosis. We studied the effect of N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine (ENMD-1068), a PAR-2 antagonist, on the development of CCl(4)-induced liver fibrosis in mice and activation of hepatic stella...

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Detalles Bibliográficos
Autores principales:	Sun, Quan, Wang, Yan, Zhang, Jie, Lu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511273/ https://www.ncbi.nlm.nih.gov/pubmed/28710422 http://dx.doi.org/10.1038/s41598-017-05190-7

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