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Changes in diet associated with cancer: An evolutionary perspective

Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes...

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Autores principales: Thomas, Frédéric, Rome, Sophie, Mery, Frédéric, Dawson, Erika, Montagne, Jacques, Biro, Peter A., Beckmann, Christa, Renaud, François, Poulin, Robert, Raymond, Michel, Ujvari, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511355/
https://www.ncbi.nlm.nih.gov/pubmed/28717385
http://dx.doi.org/10.1111/eva.12465
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author Thomas, Frédéric
Rome, Sophie
Mery, Frédéric
Dawson, Erika
Montagne, Jacques
Biro, Peter A.
Beckmann, Christa
Renaud, François
Poulin, Robert
Raymond, Michel
Ujvari, Beata
author_facet Thomas, Frédéric
Rome, Sophie
Mery, Frédéric
Dawson, Erika
Montagne, Jacques
Biro, Peter A.
Beckmann, Christa
Renaud, François
Poulin, Robert
Raymond, Michel
Ujvari, Beata
author_sort Thomas, Frédéric
collection PubMed
description Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor‐bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self‐medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression. Surprisingly, this tolerance strategy can be beneficial for the host even if diet changes are beneficial to tumor progression, provided that cancer‐induced death occurs sufficiently late (i.e., when natural selection is weak). We argue that more data and a unifying evolutionary framework, especially during the early stages of tumorigenesis, are needed to understand the links between changes in diet and tumor progression. We argue that a focus on dietary changes accompanying tumor progression can offer novel preventive and therapeutic strategies against cancer.
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spelling pubmed-55113552017-07-17 Changes in diet associated with cancer: An evolutionary perspective Thomas, Frédéric Rome, Sophie Mery, Frédéric Dawson, Erika Montagne, Jacques Biro, Peter A. Beckmann, Christa Renaud, François Poulin, Robert Raymond, Michel Ujvari, Beata Evol Appl Perspectives Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor‐bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self‐medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression. Surprisingly, this tolerance strategy can be beneficial for the host even if diet changes are beneficial to tumor progression, provided that cancer‐induced death occurs sufficiently late (i.e., when natural selection is weak). We argue that more data and a unifying evolutionary framework, especially during the early stages of tumorigenesis, are needed to understand the links between changes in diet and tumor progression. We argue that a focus on dietary changes accompanying tumor progression can offer novel preventive and therapeutic strategies against cancer. John Wiley and Sons Inc. 2017-05-20 /pmc/articles/PMC5511355/ /pubmed/28717385 http://dx.doi.org/10.1111/eva.12465 Text en © 2017 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Thomas, Frédéric
Rome, Sophie
Mery, Frédéric
Dawson, Erika
Montagne, Jacques
Biro, Peter A.
Beckmann, Christa
Renaud, François
Poulin, Robert
Raymond, Michel
Ujvari, Beata
Changes in diet associated with cancer: An evolutionary perspective
title Changes in diet associated with cancer: An evolutionary perspective
title_full Changes in diet associated with cancer: An evolutionary perspective
title_fullStr Changes in diet associated with cancer: An evolutionary perspective
title_full_unstemmed Changes in diet associated with cancer: An evolutionary perspective
title_short Changes in diet associated with cancer: An evolutionary perspective
title_sort changes in diet associated with cancer: an evolutionary perspective
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511355/
https://www.ncbi.nlm.nih.gov/pubmed/28717385
http://dx.doi.org/10.1111/eva.12465
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