Cargando…
Changes in diet associated with cancer: An evolutionary perspective
Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511355/ https://www.ncbi.nlm.nih.gov/pubmed/28717385 http://dx.doi.org/10.1111/eva.12465 |
_version_ | 1783250325946236928 |
---|---|
author | Thomas, Frédéric Rome, Sophie Mery, Frédéric Dawson, Erika Montagne, Jacques Biro, Peter A. Beckmann, Christa Renaud, François Poulin, Robert Raymond, Michel Ujvari, Beata |
author_facet | Thomas, Frédéric Rome, Sophie Mery, Frédéric Dawson, Erika Montagne, Jacques Biro, Peter A. Beckmann, Christa Renaud, François Poulin, Robert Raymond, Michel Ujvari, Beata |
author_sort | Thomas, Frédéric |
collection | PubMed |
description | Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor‐bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self‐medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression. Surprisingly, this tolerance strategy can be beneficial for the host even if diet changes are beneficial to tumor progression, provided that cancer‐induced death occurs sufficiently late (i.e., when natural selection is weak). We argue that more data and a unifying evolutionary framework, especially during the early stages of tumorigenesis, are needed to understand the links between changes in diet and tumor progression. We argue that a focus on dietary changes accompanying tumor progression can offer novel preventive and therapeutic strategies against cancer. |
format | Online Article Text |
id | pubmed-5511355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55113552017-07-17 Changes in diet associated with cancer: An evolutionary perspective Thomas, Frédéric Rome, Sophie Mery, Frédéric Dawson, Erika Montagne, Jacques Biro, Peter A. Beckmann, Christa Renaud, François Poulin, Robert Raymond, Michel Ujvari, Beata Evol Appl Perspectives Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor‐bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self‐medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression. Surprisingly, this tolerance strategy can be beneficial for the host even if diet changes are beneficial to tumor progression, provided that cancer‐induced death occurs sufficiently late (i.e., when natural selection is weak). We argue that more data and a unifying evolutionary framework, especially during the early stages of tumorigenesis, are needed to understand the links between changes in diet and tumor progression. We argue that a focus on dietary changes accompanying tumor progression can offer novel preventive and therapeutic strategies against cancer. John Wiley and Sons Inc. 2017-05-20 /pmc/articles/PMC5511355/ /pubmed/28717385 http://dx.doi.org/10.1111/eva.12465 Text en © 2017 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspectives Thomas, Frédéric Rome, Sophie Mery, Frédéric Dawson, Erika Montagne, Jacques Biro, Peter A. Beckmann, Christa Renaud, François Poulin, Robert Raymond, Michel Ujvari, Beata Changes in diet associated with cancer: An evolutionary perspective |
title | Changes in diet associated with cancer: An evolutionary perspective |
title_full | Changes in diet associated with cancer: An evolutionary perspective |
title_fullStr | Changes in diet associated with cancer: An evolutionary perspective |
title_full_unstemmed | Changes in diet associated with cancer: An evolutionary perspective |
title_short | Changes in diet associated with cancer: An evolutionary perspective |
title_sort | changes in diet associated with cancer: an evolutionary perspective |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511355/ https://www.ncbi.nlm.nih.gov/pubmed/28717385 http://dx.doi.org/10.1111/eva.12465 |
work_keys_str_mv | AT thomasfrederic changesindietassociatedwithcanceranevolutionaryperspective AT romesophie changesindietassociatedwithcanceranevolutionaryperspective AT meryfrederic changesindietassociatedwithcanceranevolutionaryperspective AT dawsonerika changesindietassociatedwithcanceranevolutionaryperspective AT montagnejacques changesindietassociatedwithcanceranevolutionaryperspective AT biropetera changesindietassociatedwithcanceranevolutionaryperspective AT beckmannchrista changesindietassociatedwithcanceranevolutionaryperspective AT renaudfrancois changesindietassociatedwithcanceranevolutionaryperspective AT poulinrobert changesindietassociatedwithcanceranevolutionaryperspective AT raymondmichel changesindietassociatedwithcanceranevolutionaryperspective AT ujvaribeata changesindietassociatedwithcanceranevolutionaryperspective |