Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to dissect lineage-specific WDR62 function(s). Interesting...

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Detalles Bibliográficos
Autores principales: Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C.H., Quinn, Leonie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511370/
https://www.ncbi.nlm.nih.gov/pubmed/28625535
http://dx.doi.org/10.1016/j.stemcr.2017.05.015

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