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How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population
KEY MESSAGE: In the QTL analysis of multi-parent populations, the inclusion of QTLs with various types of effects can lead to a better description of the phenotypic variation and increased power. ABSTRACT: For the type of QTL effect in QTL models for multi-parent populations (MPPs), various options...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511610/ https://www.ncbi.nlm.nih.gov/pubmed/28547012 http://dx.doi.org/10.1007/s00122-017-2923-3 |
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author | Garin, Vincent Wimmer, Valentin Mezmouk, Sofiane Malosetti, Marcos van Eeuwijk, Fred |
author_facet | Garin, Vincent Wimmer, Valentin Mezmouk, Sofiane Malosetti, Marcos van Eeuwijk, Fred |
author_sort | Garin, Vincent |
collection | PubMed |
description | KEY MESSAGE: In the QTL analysis of multi-parent populations, the inclusion of QTLs with various types of effects can lead to a better description of the phenotypic variation and increased power. ABSTRACT: For the type of QTL effect in QTL models for multi-parent populations (MPPs), various options exist to define them with respect to their origin. They can be modelled as referring to close parental lines or to further away ancestral founder lines. QTL models for MPPs can also be characterized by the homo- or heterogeneity of variance for polygenic effects. The most suitable model for the origin of the QTL effect and the homo- or heterogeneity of polygenic effects may be a function of the genetic distance distribution between the parents of MPPs. We investigated the statistical properties of various QTL detection models for MPPs taking into account the genetic distances between the parents of the MPP. We evaluated models with different assumptions about the QTL effect and the form of the residual term using cross validation. For the EU-NAM data, we showed that it can be useful to mix in the same model QTLs with different types of effects (parental, ancestral, or bi-allelic). The benefit of using cross-specific residual terms to handle the heterogeneity of variance was less obvious for this particular data set. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00122-017-2923-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5511610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-55116102017-07-31 How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population Garin, Vincent Wimmer, Valentin Mezmouk, Sofiane Malosetti, Marcos van Eeuwijk, Fred Theor Appl Genet Original Article KEY MESSAGE: In the QTL analysis of multi-parent populations, the inclusion of QTLs with various types of effects can lead to a better description of the phenotypic variation and increased power. ABSTRACT: For the type of QTL effect in QTL models for multi-parent populations (MPPs), various options exist to define them with respect to their origin. They can be modelled as referring to close parental lines or to further away ancestral founder lines. QTL models for MPPs can also be characterized by the homo- or heterogeneity of variance for polygenic effects. The most suitable model for the origin of the QTL effect and the homo- or heterogeneity of polygenic effects may be a function of the genetic distance distribution between the parents of MPPs. We investigated the statistical properties of various QTL detection models for MPPs taking into account the genetic distances between the parents of the MPP. We evaluated models with different assumptions about the QTL effect and the form of the residual term using cross validation. For the EU-NAM data, we showed that it can be useful to mix in the same model QTLs with different types of effects (parental, ancestral, or bi-allelic). The benefit of using cross-specific residual terms to handle the heterogeneity of variance was less obvious for this particular data set. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00122-017-2923-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2017-05-25 2017 /pmc/articles/PMC5511610/ /pubmed/28547012 http://dx.doi.org/10.1007/s00122-017-2923-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Garin, Vincent Wimmer, Valentin Mezmouk, Sofiane Malosetti, Marcos van Eeuwijk, Fred How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title | How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title_full | How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title_fullStr | How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title_full_unstemmed | How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title_short | How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population |
title_sort | how do the type of qtl effect and the form of the residual term influence qtl detection in multi-parent populations? a case study in the maize eu-nam population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511610/ https://www.ncbi.nlm.nih.gov/pubmed/28547012 http://dx.doi.org/10.1007/s00122-017-2923-3 |
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