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Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease
BACKGROUND: Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatme...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511636/ https://www.ncbi.nlm.nih.gov/pubmed/28751912 http://dx.doi.org/10.1155/2017/1908768 |
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author | Elsaadany, Basma Abdelaleem Ahmed, Eman Magdy Aghbary, Sana Maher Hasan |
author_facet | Elsaadany, Basma Abdelaleem Ahmed, Eman Magdy Aghbary, Sana Maher Hasan |
author_sort | Elsaadany, Basma Abdelaleem |
collection | PubMed |
description | BACKGROUND: Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence. OBJECTIVE: This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD. DATA SOURCES: Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016. DATA EXTRACTION: Extracted pieces of information were intervention, population, sample sizes, and outcomes. DATA SYNTHESIS: Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial. RESULTS: There is a limited evidence concerning clinical efficacy of topical corticosteroids. Clobetasol, dexamethasone, and budesonide were the topical corticosteroid of choice. The highest level of evidence score was given to clobetasol followed by budesonide with a lower evidence level. CONCLUSION: All three topical corticosteroid preparations are effective for management of oral chronic GVHD with minimal easily avoided side effects. |
format | Online Article Text |
id | pubmed-5511636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55116362017-07-27 Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease Elsaadany, Basma Abdelaleem Ahmed, Eman Magdy Aghbary, Sana Maher Hasan Int J Dent Review Article BACKGROUND: Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence. OBJECTIVE: This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD. DATA SOURCES: Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016. DATA EXTRACTION: Extracted pieces of information were intervention, population, sample sizes, and outcomes. DATA SYNTHESIS: Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial. RESULTS: There is a limited evidence concerning clinical efficacy of topical corticosteroids. Clobetasol, dexamethasone, and budesonide were the topical corticosteroid of choice. The highest level of evidence score was given to clobetasol followed by budesonide with a lower evidence level. CONCLUSION: All three topical corticosteroid preparations are effective for management of oral chronic GVHD with minimal easily avoided side effects. Hindawi 2017 2017-07-02 /pmc/articles/PMC5511636/ /pubmed/28751912 http://dx.doi.org/10.1155/2017/1908768 Text en Copyright © 2017 Basma Abdelaleem Elsaadany et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Elsaadany, Basma Abdelaleem Ahmed, Eman Magdy Aghbary, Sana Maher Hasan Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title | Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title_full | Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title_fullStr | Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title_full_unstemmed | Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title_short | Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease |
title_sort | efficacy and safety of topical corticosteroids for management of oral chronic graft versus host disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511636/ https://www.ncbi.nlm.nih.gov/pubmed/28751912 http://dx.doi.org/10.1155/2017/1908768 |
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