Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy

Chronic lymphocytic leukemia (CLL) is an incurable lymphoproliferative disorder with a heterogeneous genetic and clinical course. Two kinase inhibitors, ibrutinib and idelalisib, have demonstrated achievement of complete and durable remissions in relapse/refractory genetically unselected CLL patient...

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Autores principales: Velasco-Rodríguez, Diego, Piris-Villaespesa, Miguel, Soteras, Carmen, Vallés, Ana, García-Marco, José Antonio, García-Vela, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511649/
https://www.ncbi.nlm.nih.gov/pubmed/28751992
http://dx.doi.org/10.1155/2017/3869020
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author Velasco-Rodríguez, Diego
Piris-Villaespesa, Miguel
Soteras, Carmen
Vallés, Ana
García-Marco, José Antonio
García-Vela, José Antonio
author_facet Velasco-Rodríguez, Diego
Piris-Villaespesa, Miguel
Soteras, Carmen
Vallés, Ana
García-Marco, José Antonio
García-Vela, José Antonio
author_sort Velasco-Rodríguez, Diego
collection PubMed
description Chronic lymphocytic leukemia (CLL) is an incurable lymphoproliferative disorder with a heterogeneous genetic and clinical course. Two kinase inhibitors, ibrutinib and idelalisib, have demonstrated achievement of complete and durable remissions in relapse/refractory genetically unselected CLL patients. We present a case of relapsed CLL with extensive disease and hourglass deformity of urinary bladder as a result of the compression of two extraperitoneal paravesical soft tissue bulky masses, with excellent response to sequential kinase inhibitor therapy.
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spelling pubmed-55116492017-07-27 Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy Velasco-Rodríguez, Diego Piris-Villaespesa, Miguel Soteras, Carmen Vallés, Ana García-Marco, José Antonio García-Vela, José Antonio Case Rep Hematol Case Report Chronic lymphocytic leukemia (CLL) is an incurable lymphoproliferative disorder with a heterogeneous genetic and clinical course. Two kinase inhibitors, ibrutinib and idelalisib, have demonstrated achievement of complete and durable remissions in relapse/refractory genetically unselected CLL patients. We present a case of relapsed CLL with extensive disease and hourglass deformity of urinary bladder as a result of the compression of two extraperitoneal paravesical soft tissue bulky masses, with excellent response to sequential kinase inhibitor therapy. Hindawi 2017 2017-07-02 /pmc/articles/PMC5511649/ /pubmed/28751992 http://dx.doi.org/10.1155/2017/3869020 Text en Copyright © 2017 Diego Velasco-Rodríguez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Velasco-Rodríguez, Diego
Piris-Villaespesa, Miguel
Soteras, Carmen
Vallés, Ana
García-Marco, José Antonio
García-Vela, José Antonio
Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title_full Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title_fullStr Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title_full_unstemmed Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title_short Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy
title_sort prostatic-like syndrome in a woman with chronic lymphocytic leukemia: sequential kinase inhibitor therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511649/
https://www.ncbi.nlm.nih.gov/pubmed/28751992
http://dx.doi.org/10.1155/2017/3869020
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