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Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell's capacity to transfer these organelle...

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Autores principales: Caicedo, Andrés, Aponte, Pedro M., Cabrera, Francisco, Hidalgo, Carmen, Khoury, Maroun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511681/
https://www.ncbi.nlm.nih.gov/pubmed/28751917
http://dx.doi.org/10.1155/2017/7610414
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author Caicedo, Andrés
Aponte, Pedro M.
Cabrera, Francisco
Hidalgo, Carmen
Khoury, Maroun
author_facet Caicedo, Andrés
Aponte, Pedro M.
Cabrera, Francisco
Hidalgo, Carmen
Khoury, Maroun
author_sort Caicedo, Andrés
collection PubMed
description The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell's capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine.
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spelling pubmed-55116812017-07-27 Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications Caicedo, Andrés Aponte, Pedro M. Cabrera, Francisco Hidalgo, Carmen Khoury, Maroun Stem Cells Int Review Article The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell's capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine. Hindawi 2017 2017-07-02 /pmc/articles/PMC5511681/ /pubmed/28751917 http://dx.doi.org/10.1155/2017/7610414 Text en Copyright © 2017 Andrés Caicedo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Caicedo, Andrés
Aponte, Pedro M.
Cabrera, Francisco
Hidalgo, Carmen
Khoury, Maroun
Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title_full Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title_fullStr Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title_full_unstemmed Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title_short Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
title_sort artificial mitochondria transfer: current challenges, advances, and future applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511681/
https://www.ncbi.nlm.nih.gov/pubmed/28751917
http://dx.doi.org/10.1155/2017/7610414
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