Cargando…

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

Worldwide, metabolic diseases such as obesity and type 2 diabetes have reached epidemic proportions. A major regulator of metabolic processes that gained interest in recent years is the bile acid receptor TGR5 (Takeda G protein-coupled receptor 5). This G protein-coupled membrane receptor can be fou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ladurner, Angela, Zehl, Martin, Grienke, Ulrike, Hofstadler, Christoph, Faur, Nadina, Pereira, Fátima C., Berry, David, Dirsch, Verena M., Rollinger, Judith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511840/ https://www.ncbi.nlm.nih.gov/pubmed/28769799 http://dx.doi.org/10.3389/fphar.2017.00468

Ejemplares similares

In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1
por: Kirchweger, Benjamin, et al.
Publicado: (2018)

Anti-Influenza Triterpene Saponins from the Bark of Burkea africana
por: Mair, Christina E., et al.
Publicado: (2018)

Central anorexigenic actions of bile acids are mediated by TGR5
por: Perino, Alessia, et al.
Publicado: (2021)

Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
por: Keitel, Verena, et al.
Publicado: (2014)

The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
por: Qi, Youchao, et al.
Publicado: (2022)

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
por: Hov, Johannes R., et al.
Publicado: (2010)

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
por: Bidault-Jourdainne, Valeska, et al.
Publicado: (2020)

A Biochemometric Approach for the Identification of In Vitro Anti-Inflammatory Constituents in Masterwort
por: Zwirchmayr, Julia, et al.
Publicado: (2020)

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5
por: Trammell, Samuel A. J., et al.
Publicado: (2020)

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
por: Jadhav, Kavita, et al.
Publicado: (2018)

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
por: Miyata, Sachiho, et al.
Publicado: (2021)

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction
por: Leonhardt, Julia, et al.
Publicado: (2021)

Taurochenodeoxycholic Acid Increases cAMP Content via Specially Interacting with Bile Acid Receptor TGR5
por: Qi, Youchao, et al.
Publicado: (2021)

The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic syndrome
por: Stepanov, Vanesa, et al.
Publicado: (2012)

Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum
por: Grienke, Ulrike, et al.
Publicado: (2011)

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver
por: Klindt, Caroline, et al.
Publicado: (2019)

Editorial: Rising stars in ethnopharmacology: 2021
por: Grienke, Ulrike, et al.
Publicado: (2023)

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells
por: Lou, Guiyu, et al.
Publicado: (2014)

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia
por: Chen, Min-Chan, et al.
Publicado: (2016)

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
por: Chen, Geng, et al.
Publicado: (2020)

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain
por: Wu, Yuning, et al.
Publicado: (2023)

Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells
por: Li, Dan, et al.
Publicado: (2016)

Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5
por: Abrigo, Johanna, et al.
Publicado: (2020)

Evaluation of G-Protein-Coupled Bile Acid Receptor 1 (TGR5) Levels in Intrahepatic Cholestasis of Pregnancy
por: Irak, Kader, et al.
Publicado: (2021)

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2011)

Identification of miR-26a as a Target Gene of Bile Acid Receptor GPBAR-1/TGR5
por: Chen, Xiaosong, et al.
Publicado: (2015)

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
por: Ni, Zhen, et al.
Publicado: (2020)

Bile Acids Induce Neurite Outgrowth in Nsc-34 Cells via TGR5 and a Distinct Transcriptional Profile
por: Ackerman, Hayley D., et al.
Publicado: (2023)

Optimization of Green Synthesis of Silver Nanoparticles from Leaf Extracts of Pimenta dioica (Allspice)
por: Geetha, Akshay Rajeev, et al.
Publicado: (2013)

Chemical Composition, Insecticidal and Mosquito Larvicidal Activities of Allspice (Pimenta dioica) Essential Oil
por: Narayanankutty, Arunaksharan, et al.
Publicado: (2021)

Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways
por: Baptissart, Marine, et al.
Publicado: (2018)

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2013)

The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5
por: Baars, Annemarie, et al.
Publicado: (2015)

Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5
por: Ibrahim, Effendi, et al.
Publicado: (2018)

Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5
por: Guo, Jielong, et al.
Publicado: (2019)

Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis
por: Spatz, Madeleine, et al.
Publicado: (2021)

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells
por: Ladurner, Angela, et al.
Publicado: (2012)

Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort
por: Zwirchmayr, Julia, et al.
Publicado: (2023)

Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown
por: Teodoro, João S., et al.
Publicado: (2021)

Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis
por: Miyazaki-Anzai, Shinobu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0b9r7nbd293fo9mlr05isq0u12