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Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System

The purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters...

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Autores principales: Lassen, Martin L., Muzik, Otto, Beyer, Thomas, Hacker, Marcus, Ladefoged, Claes Nøhr, Cal-González, Jacobo, Wadsak, Wolfgang, Rausch, Ivo, Langer, Oliver, Bauer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511842/
https://www.ncbi.nlm.nih.gov/pubmed/28769742
http://dx.doi.org/10.3389/fnins.2017.00396
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author Lassen, Martin L.
Muzik, Otto
Beyer, Thomas
Hacker, Marcus
Ladefoged, Claes Nøhr
Cal-González, Jacobo
Wadsak, Wolfgang
Rausch, Ivo
Langer, Oliver
Bauer, Martin
author_facet Lassen, Martin L.
Muzik, Otto
Beyer, Thomas
Hacker, Marcus
Ladefoged, Claes Nøhr
Cal-González, Jacobo
Wadsak, Wolfgang
Rausch, Ivo
Langer, Oliver
Bauer, Martin
author_sort Lassen, Martin L.
collection PubMed
description The purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters as a function of PET system choice have been investigated. Five healthy volunteers underwent dynamic (R)-[(11)C]verapamil imaging on the same day using a GE-Advance (PET-only) and a Siemens Biograph mMR system (PET/MR). PET-emission data were reconstructed using a transmission-based attenuation correction (AC) map (PET-only), whereas a standard MR-DIXON as well as a low-dose CT AC map was applied to PET/MR emission data. Kinetic modeling based on arterial blood sampling was performed using a 1-tissue-2-rate constant compartment model, yielding kinetic parameters (K(1) and k(2)) and distribution volume (V(T)). Differences for parametric values obtained in the PET-only and the PET/MR systems were analyzed using a 2-way Analysis of Variance (ANOVA). Comparison of DIXON-based AC (PET/MR) with emission data derived from the PET-only system revealed average inter-system differences of −33 ± 14% (p < 0.05) for the K(1) parameter and −19 ± 9% (p < 0.05) for k(2). Using a CT-based AC for PET/MR resulted in slightly lower systematic differences of −16 ± 18% for K(1) and −9 ± 10% for k(2). The average differences in V(T) were −18 ± 10% (p < 0.05) for DIXON- and −8 ± 13% for CT-based AC. Significant systematic differences were observed for kinetic parameters derived from emission data obtained from PET/MR and PET-only imaging due to different standard AC methods employed. Therefore, a transfer of imaging protocols from PET-only to PET/MR systems is not straightforward without application of proper correction methods. Clinical Trial Registration: www.clinicaltrialsregister.eu, identifier 2013-001724-19
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spelling pubmed-55118422017-08-02 Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System Lassen, Martin L. Muzik, Otto Beyer, Thomas Hacker, Marcus Ladefoged, Claes Nøhr Cal-González, Jacobo Wadsak, Wolfgang Rausch, Ivo Langer, Oliver Bauer, Martin Front Neurosci Neuroscience The purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters as a function of PET system choice have been investigated. Five healthy volunteers underwent dynamic (R)-[(11)C]verapamil imaging on the same day using a GE-Advance (PET-only) and a Siemens Biograph mMR system (PET/MR). PET-emission data were reconstructed using a transmission-based attenuation correction (AC) map (PET-only), whereas a standard MR-DIXON as well as a low-dose CT AC map was applied to PET/MR emission data. Kinetic modeling based on arterial blood sampling was performed using a 1-tissue-2-rate constant compartment model, yielding kinetic parameters (K(1) and k(2)) and distribution volume (V(T)). Differences for parametric values obtained in the PET-only and the PET/MR systems were analyzed using a 2-way Analysis of Variance (ANOVA). Comparison of DIXON-based AC (PET/MR) with emission data derived from the PET-only system revealed average inter-system differences of −33 ± 14% (p < 0.05) for the K(1) parameter and −19 ± 9% (p < 0.05) for k(2). Using a CT-based AC for PET/MR resulted in slightly lower systematic differences of −16 ± 18% for K(1) and −9 ± 10% for k(2). The average differences in V(T) were −18 ± 10% (p < 0.05) for DIXON- and −8 ± 13% for CT-based AC. Significant systematic differences were observed for kinetic parameters derived from emission data obtained from PET/MR and PET-only imaging due to different standard AC methods employed. Therefore, a transfer of imaging protocols from PET-only to PET/MR systems is not straightforward without application of proper correction methods. Clinical Trial Registration: www.clinicaltrialsregister.eu, identifier 2013-001724-19 Frontiers Media S.A. 2017-07-17 /pmc/articles/PMC5511842/ /pubmed/28769742 http://dx.doi.org/10.3389/fnins.2017.00396 Text en Copyright © 2017 Lassen, Muzik, Beyer, Hacker, Ladefoged, Cal-González, Wadsak, Rausch, Langer and Bauer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lassen, Martin L.
Muzik, Otto
Beyer, Thomas
Hacker, Marcus
Ladefoged, Claes Nøhr
Cal-González, Jacobo
Wadsak, Wolfgang
Rausch, Ivo
Langer, Oliver
Bauer, Martin
Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title_full Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title_fullStr Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title_full_unstemmed Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title_short Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
title_sort reproducibility of quantitative brain imaging using a pet-only and a combined pet/mr system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511842/
https://www.ncbi.nlm.nih.gov/pubmed/28769742
http://dx.doi.org/10.3389/fnins.2017.00396
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