DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter

In cardiac myocytes, regulation of mitochondrial Ca(2+) is important for cellular signaling and cardiac contraction. Ca(2+) entry into the mitochondria is mediated by a highly selective Ca(2+) channel called the mitochondrial calcium uniporter, which consists of a pore-forming subunit MCU and regula...

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Detalles Bibliográficos
Autores principales: Kon, Naohiro, Murakoshi, Michiko, Isobe, Aya, Kagechika, Katsuji, Miyoshi, Naoki, Nagayama, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511861/
https://www.ncbi.nlm.nih.gov/pubmed/28725491
http://dx.doi.org/10.1038/cddiscovery.2017.45

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